Drug is the primary key and drug discovery is the program of pharmaceutical-art for disease management. The scenario of designing potential-drugs based on identification of therapeutic targets through pathogenesis and screening of active principles by lead identification and optimization. Final stage of existing drug discovery processes brings only less than 1% of drug candidate to market research and its results shown the economic impact of drug discovery program. Hence drug designing is the most vital curriculum to save the expenditure of drug discovery and development process. The extensive perceptions of drug design in addition to the knowledge and skills in attendance have structured by the role of countless experts. Still, some fascinating confronts yet to be enlightened. Here, I summarize the significance and need of drug design. (Ref: Seenivasagam R. Drug Design: Signature of Drug Discovery. Drug Discovery, 2020, 14(33), 1-8).
Drug is the primary key and drug discovery is the program of pharmaceutical-art for disease management. The scenario of designing potential-drugs based on identification of therapeutic targets through pathogenesis and screening of active principles by lead identification and optimization.
The use of herbal medicine in Nigeria is on the increase but unknowingly to consumers, these herbal products may pose severe and devastating health hazards. This study was aimed at studying the adverse impacts posed by either the ethanolic extract of root
Traditional healers and many local residents in Nigeria use a wide range of medicinal plants in the treatment of diarrhea. Glyphaea brevis is one of such plants claimed to have antidiarrheal property. This study investigated the antidiarrheal effects of
The L. barteri leaf extract and fractions were assessed for their anti-inflammatory potentials. The extract (200 and 400 mg/kg) and fractions (400 mg/kg)were employed in egg albumin-induced edema while 3% Tween 80 and piroxicam (50 mg/kg)
The immense contribution of structure based drug design in the field of drug discovery is noteworthy. Molecular docking methodology has drawn considerable attention in it. Observing multiple affinities in a single chemical entity is one of the biggest challenges in modern drug discovery
Twenty-five (25) mature albino Wistar rats weighing between 175g-200g were divided into five groups of five rats each, based on their body weights. Group A served as the control and received normal feed and clean tap water orally for 7 days.
Traditional medicine has been of immense importance to the world teeming populace. A total of (16) sixteen rats were used for this investigation to affirm the traditional use of Lantana camara in the treatment of ulcer
Coffee is thought to have originated in the Ethiopian province of Kaffa and brought out of Africa and the Arab world by the Dutch. It is now consumed worldwide and its popularity is growing
Fast disintegrating tablets are solid dosage forms that disintegrate rapidly without chewing upon contact with saliva in the oral cavity
The rationale of this research was to formulate and evaluate a gastro-retentive floating drug delivery system of Baclofen. Sustained release gastro-retentive dosage forms enable prolonged and continuous input of the drug
The study investigated the sustain drug release ability of Sus scrofa domesticus (SSD) fat in comparison with carnauba wax in ibuprofen matrix granule formulations.
Vitamin D, a multipurpose steroid hormone, is vital to health. Vitamin D deficiency is present in approximately 30% to 50% of the general population. Its deficiency is now considered a worldwide pandemic.
Metal complexes of the type ML2X2 (where M = Cu (II), Co (II) and Ni (II), L= 2-amino-4-(p-hydroxy phenyl)thiazole and X= cl- , CH3COO- ) were prepared and characterized with the help of their elemental analysis, IR, electronic and magnetic susceptibility studies
Polypharmacy is common in the elderly. It continues to increase, despite its known association with increased morbidity and mortality. It increases the risk of inappropriate use of medications, nonadherence, and adverse effects.
The aim of this study was to investigate the acute toxicity of ARTHA GO capsule using Wistar rat. Acute toxicity study was performed using OECD guidelines 421, a dose of (5mg/kg, 50mg/kg, 300mg/kg or 2000mg/kg) body weight administered orally to rats.
Thyroid hormones play an important role in glucose metabolism and homeostasis. This review focuses on the relationship between oxidative stress and disruption of thyroid hormones in association with gestational diabetes.
Hepatocellular carcinoma (HCC) is the most frequent and predominant malignant tumor of the liver having a grave prognosis, and regularly diagnosed at an advanced stage.
Anisochilus carnosus (Lamiaceae) is annual herb with traditional medicinal properties as antiulcer, expectorant, stimulant and antihepatic agent. It is rich in phytochemical composition especially phenolic compounds
The objective of the present study was to investigate the performance, haemato-biochemical parameters of broiler chicks administered Daniellia oliveri leaf extract (DOE) as an antibiotic alternative
The study was designed to evaluate the carcass quality, nutrient retention and caeca microbial population of broiler chicks administered Daniellia oliveri leaf extract (DOE) as an antibiotic alternative
Introduction: Analgesic (for both neuropathic and nociceptive pain) and anticonvulsant action of 7-bromo-5-(o-chlorophenyl)-3- propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one (propoxazepam) make it perspective for further studying
There has recently been increased understanding of the role of maternal oral health and its possible health impacts. This study was conducted during pregnancy to evaluate the awareness of pregnant women regarding oral health
Background: Lead is known to be a toxic substance which affects the liver, kidney and the brain by inducing oxidative stress owing to elevation of reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide, hydroxyl radicals and lipid peroxides
In the past decades, the incidence of opportunistic fungal infections has increased tremendously and the spectrum of fungal pathogens has changed.
