Drug Discovery

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Volume 14, Issue 33, 2020

About the Cover

Drug is the primary key and drug discovery is the program of pharmaceutical-art for disease management. The scenario of designing potential-drugs based on identification of therapeutic targets through pathogenesis and screening of active principles by lead identification and optimization. Final stage of existing drug discovery processes brings only less than 1% of drug candidate to market research and its results shown the economic impact of drug discovery program. Hence drug designing is the most vital curriculum to save the expenditure of drug discovery and development process. The extensive perceptions of drug design in addition to the knowledge and skills in attendance have structured by the role of countless experts. Still, some fascinating confronts yet to be enlightened. Here, I summarize the significance and need of drug design. (Ref: Seenivasagam R. Drug Design: Signature of Drug Discovery. Drug Discovery, 2020, 14(33), 1-8).


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EDITORIAL

Drug Design: Signature of Drug Discovery

Seenivasagam R

Drug is the primary key and drug discovery is the program of pharmaceutical-art for disease management. The scenario of designing potential-drugs based on identification of therapeutic targets through pathogenesis and screening of active principles by lead identification and optimization.

Drug Discovery, 2020, 14(33), 1-8

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ANALYSIS

Comparative analysis of the negative impact of ethanolic root bark and leaf extracts of Rauwofia vomitoria (apocynaceae) on cerebellar glycogen in adult wistar rats

Akaninyene M. Okon, Mokutima A. Eluwa, Clementina F. Iniodu, Gabriel D. Edem, Ekaette P. Akpan

The use of herbal medicine in Nigeria is on the increase but unknowingly to consumers, these herbal products may pose severe and devastating health hazards. This study was aimed at studying the adverse impacts posed by either the ethanolic extract of root

Drug Discovery, 2020, 14(33), 9-15

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RESEARCH

Evaluation of the effectiveness of the methanol leaf extract and fractions of Glyphaea brevis (Spreng) Monach (Malvaceae) used in the treatment of diarrhea in Nigeria

Martha N Ofokansi, Pleasant A Ihuoma, Matthias O Agbo, Ogechukwu N Isiogugu, Ikechukwu E Peter, Philip E Ugwuoke, Peter A Akah

Traditional healers and many local residents in Nigeria use a wide range of medicinal plants in the treatment of diarrhea. Glyphaea brevis is one of such plants claimed to have antidiarrheal property. This study investigated the antidiarrheal effects of

Drug Discovery, 2020, 14(33), 16-24

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ANALYSIS

Anti-inflammatory activity of the methanol leaf extract and fractions of Lannea barteri Oliv. Engl. (Anacardiaceae) in rats

Mbaoji F.N, Peter I.E, Onwuka A.M

The L. barteri leaf extract and fractions were assessed for their anti-inflammatory potentials. The extract (200 and 400 mg/kg) and fractions (400 mg/kg)were employed in egg albumin-induced edema while 3% Tween 80 and piroxicam (50 mg/kg)

Drug Discovery, 2020, 14(33), 25-32

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REPORT

Virtual screening of few novel Sulindac derivatives as multi-targeted agents

Arka Das, Sudipta Nandi, Kingshuk Das, Subhasis Banerjee

The immense contribution of structure based drug design in the field of drug discovery is noteworthy. Molecular docking methodology has drawn considerable attention in it. Observing multiple affinities in a single chemical entity is one of the biggest challenges in modern drug discovery

Drug Discovery, 2020, 14(33), 33-43

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ANALYSIS

Ascertaining the protective properties of Carica Papaya on the liver of albino wistar rats induced with carbon tetrachloride

Kingsley A. Okon, Akpan U. Ekanem, Gabriel D. Edem, Eno-obong B. Ikpeme, Aniebiet A. Udo

Twenty-five (25) mature albino Wistar rats weighing between 175g-200g were divided into five groups of five rats each, based on their body weights. Group A served as the control and received normal feed and clean tap water orally for 7 days.

Drug Discovery, 2020, 14(33), 44-49

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Lantana camara ameliorates gastric ulcer in aspirin-induced ulcer in wistar rats

Gabriel D. Edem, Sarah I. Essien, Akpan U. Ekanem, Kingsley A. Okon, Samuel S. Gabriel

Traditional medicine has been of immense importance to the world teeming populace. A total of (16) sixteen rats were used for this investigation to affirm the traditional use of Lantana camara in the treatment of ulcer

Drug Discovery, 2020, 14(33), 50-56

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Coffee: A Therapeutic Beverage

Shashi K Agarwal

Coffee is thought to have originated in the Ethiopian province of Kaffa and brought out of Africa and the Arab world by the Dutch. It is now consumed worldwide and its popularity is growing

Drug Discovery, 2020, 14(33), 57-60

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Optimization of a blend of natural and synthetic disintegrants in the formulation of fast disintegration tablets of Salbutamol

Yiobor Ogoh, Sylvester O Eraga, Magnus A Iwuagwu

Fast disintegrating tablets are solid dosage forms that disintegrate rapidly without chewing upon contact with saliva in the oral cavity

Drug Discovery, 2020, 14(33), 61-70

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RESEARCH

An innovative floating gastro-retentive drug system: Design, formulation and in vitro evaluation

Kanaka Durga Devi N, Arun Y, Narasimha Rao N, Nikhitha P, Hemalatha B

The rationale of this research was to formulate and evaluate a gastro-retentive floating drug delivery system of Baclofen. Sustained release gastro-retentive dosage forms enable prolonged and continuous input of the drug

Drug Discovery, 2020, 14(33), 71-79

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ANALYSIS

A comparative evaluation of the sustained release properties of Sus scrofa domesticus fat and carnauba wax in ibuprofen matrix granule formulations

Cyprian O Uzochukwu, Sylvester O Eraga, Florence E Eichie

The study investigated the sustain drug release ability of Sus scrofa domesticus (SSD) fat in comparison with carnauba wax in ibuprofen matrix granule formulations.

Drug Discovery, 2020, 14(33), 80-89

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OPINION

Schizophrenia and Vitamin D deficiency

Shashi K Agarwal

Vitamin D, a multipurpose steroid hormone, is vital to health. Vitamin D deficiency is present in approximately 30% to 50% of the general population. Its deficiency is now considered a worldwide pandemic.

Drug Discovery, 2020, 14(33), 90-96

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REPORT

Studies on structural and biological aspects of transition metal complexes of the ligand 2- Amino -4-(P-Hydroxy Phenyl) Thiazole

Dinkar Malik, Punam Yadav, Sandeep Kumar, Vijai Malik

Metal complexes of the type ML2X2 (where M = Cu (II), Co (II) and Ni (II), L= 2-amino-4-(p-hydroxy phenyl)thiazole and X= cl- , CH3COO- ) were prepared and characterized with the help of their elemental analysis, IR, electronic and magnetic susceptibility studies

Drug Discovery, 2020, 14(33), 97-99

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Polypharmacy in Elderly Patients with Hypertension

Agarwal N, Agarwal S

Polypharmacy is common in the elderly. It continues to increase, despite its known association with increased morbidity and mortality. It increases the risk of inappropriate use of medications, nonadherence, and adverse effects.

Drug Discovery, 2020, 14(33), 100-105

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ANALYSIS

Acute toxicity study on ARTHA GO capsules by using wistar rats

Manish P. Deshmukh, Sayali V. kathale, Ashish Budhrani, A.J. Anjankar

The aim of this study was to investigate the acute toxicity of ARTHA GO capsule using Wistar rat. Acute toxicity study was performed using OECD guidelines 421, a dose of (5mg/kg, 50mg/kg, 300mg/kg or 2000mg/kg) body weight administered orally to rats.

Drug Discovery, 2020, 14(33), 106-111

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REVIEW

Drugs therapy against dysthyroidism induced oxidative stress in pregnant women with Gestational Diabetes Mellitus - a review

Samir Derouiche, Chaima Djaballah, Basma Chihani

Thyroid hormones play an important role in glucose metabolism and homeostasis. This review focuses on the relationship between oxidative stress and disruption of thyroid hormones in association with gestational diabetes.

Drug Discovery, 2020, 14(33), 112-118

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Hepatocellular carcinoma pathogenesis and diagnostic Novel biomarkers: A pathological systemic review

Abhishek Soni, Madhav Nilakanth Mugale

Hepatocellular carcinoma (HCC) is the most frequent and predominant malignant tumor of the liver having a grave prognosis, and regularly diagnosed at an advanced stage.

Drug Discovery, 2020, 14(33), 119-129

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REPORT

A report on identification of a unique hygrine like compound from chloroform extract of Anisochilus carnosus (L.f.) Wall

Rupali P. Shirsat, Syed Imran, Deepak K. Koche

Anisochilus carnosus (Lamiaceae) is annual herb with traditional medicinal properties as antiulcer, expectorant, stimulant and antihepatic agent. It is rich in phytochemical composition especially phenolic compounds

Drug Discovery, 2020, 14(33), 130-134

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ANALYSIS

Performance, haemato-biochemical parameters of broiler chicks administered Rolfe (Daniellia oliveri) leaf extract as an antibiotic alternative

Olafadehan O.A, Oluwafemi R.A, Alagbe J.O

The objective of the present study was to investigate the performance, haemato-biochemical parameters of broiler chicks administered Daniellia oliveri leaf extract (DOE) as an antibiotic alternative

Drug Discovery, 2020, 14(33), 135-145

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Carcass quality, nutrient retention and Caeca microbial population of broiler chicks administered Rolfe (Daniellia oliveri) leaf extract as an antibiotic alternative

Olafadehan OA. Oluwafemi RA, Alagbe JO

The study was designed to evaluate the carcass quality, nutrient retention and caeca microbial population of broiler chicks administered Daniellia oliveri leaf extract (DOE) as an antibiotic alternative

Drug Discovery, 2020, 14(33), 146-154

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RESEARCH

Sedative-hypnotic and muscle relaxant activities of propoxazepam in animal models and investigation on possible mechanisms

Mykola Golovenko, Vitalii Larionov, Anatoliy Reder, Iryna Valivodz, Zhanna Tsapenko

Introduction: Analgesic (for both neuropathic and nociceptive pain) and anticonvulsant action of 7-bromo-5-(o-chlorophenyl)-3- propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one (propoxazepam) make it perspective for further studying

Drug Discovery, 2020, 14(33), 155-162

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ANALYSIS

Oral health awareness among pregnant women in Upper Egypt

Noha M. Ali Abdalla, Ayat M. Omar Masoud, Ekbal A. Emam, Ahmad S. Abd EL-Male

There has recently been increased understanding of the role of maternal oral health and its possible health impacts. This study was conducted during pregnancy to evaluate the awareness of pregnant women regarding oral health

Drug Discovery, 2020, 14(33), 163-169

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Ethanol extract of Myristica fragrans (houtt) exhibits hepato-renal protective effects against lead-induced toxicity in Wistar rats

Olubayode Bamidele, Olajide Adebayo, Lawrence Dayo Adedayo, Olugbenga Samuel. Michael, Alaba Olumide Ojo, Dennis Seyi Arokoyo

Background: Lead is known to be a toxic substance which affects the liver, kidney and the brain by inducing oxidative stress owing to elevation of reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide, hydroxyl radicals and lipid peroxides

Drug Discovery, 2020, 14(33), 170-179

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Evaluation of antifungal potential of synthesized metal complexes against Trichophyton tonsurans using molecular docking approach

David OM, Akeke E, Olagboye SA, Owabumoye JB

In the past decades, the incidence of opportunistic fungal infections has increased tremendously and the spectrum of fungal pathogens has changed.

Drug Discovery, 2020, 14(33), 180-188

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© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution License 4.0 (CC BY 4.0).