Volume 14, Issue 33, January - June, 2020

Ascertaining the protective properties of Carica Papaya on the liver of albino wistar rats induced with carbon tetrachloride

Kingsley A. Okon^♦, Akpan U. Ekanem, Gabriel D. Edem, Eno-obong B. Ikpeme, Aniebiet A. Udo

Department of Anatomy, College of Health Sciences, University of Uyo

^♦Corresponding author
Department of Anatomy, College of Health Sciences, University of Uyo. Email: kingsleyokon407@gmail.com

ABSTRACT

Twenty-five (25) mature albino Wistar rats weighing between 175g-200g were divided into five groups of five rats each, based on their body weights. Group A served as the control and received normal feed and clean tap water orally for 7 days. Group B animals received 2.5ml/kg body weight of carbon tetrachloride (CCl4) on the first day of administration only. Group C animals were administered with 2.5ml/kg body weight of carbon tetrachloride (CCl4) on the first day of administration and 100mg/kg body weight of the bark (peel) of ripe carica papaya extract dissolved in 2ml of distilled water orally, once for 7 days. Group D received 2.5ml/kg body weight of CCL4 on the first day of administration and 200mg/kg body weight of extract dissolved in 2ml of distilled water orally, once daily for 7 days. Group E received 2.5ml/kg of carbon tetrachloride (CCl4) on the first day of administration and 300mg/kg body weight of extract dissolved in 2ml of distilled water orally, once daily for 7 days. The animals were sacrificed on the 8th day, the liver removed and processed for Haematoxylin and Eosin staining. Histological results revealed irreversible area of chronic inflammation, sinusoidal enlargement, vascular degeneration, vascular congestion and cellular proliferation with pyknotic nucleus in the treated groups when compared with the control group with normal cellular architecture. This reveals that bark peel of ripe Carica papaya fruit exerted little or no hepatoprotective impact on the liver of rats administered with CCl4.

Keywords: Liver, carbon tetrachloride (CCl4), Carica papaya

Drug Discovery, 2020, 14(33), 44-49

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