Volume 14, Issue 33, January - June, 2020

Drugs therapy against dysthyroidism induced oxidative stress in pregnant women with Gestational Diabetes Mellitus

Samir Derouiche^1,2♦, Chaima Djaballah¹, Basma Chihani¹

¹Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria
²Laboratory of Biodiversity and application of biotechnology in the agricultural field, Faculty of natural sciences and life, University of El Oued, El-Oued 39000, Algeria

^♦Corresponding author
Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria / Laboratory of Biodiversity and application of biotechnology in the agricultural field, Faculty of natural sciences and life, University of El Oued, El-Oued 39000, Algeria

ABSTRACT

Thyroid hormones play an important role in glucose metabolism and homeostasis. This review focuses on the relationship between oxidative stress and disruption of thyroid hormones in association with gestational diabetes. During a normal pregnancy, oxidative stress enhances antioxidant mechanisms, thyroid hormones play particularly important role that operate on the antioxidant balance, during pregnancy a severe iodine deficiency would affect the synthesis and secretion of T4 or T3 which stimulates excretion of TSH which shown associated with oxidative stress by, increase the production of reactive oxygen species and changes in anti-oxidative factors. Increased oxidative stress is a widely accepted participant in the development and progression of diabetic tissue damage during pregnancy or what we call gestational diabetes. This study highlights the importance of evaluating and controlling the variation of thyroid hormones and the oxidative stress markers in pregnant women to properly control the complications of pregnancy including gestational diabetes, suggesting to use antioxidant supplements with the systematic treatment of gestational diabetes or dysthyroid to protect against complications of pregnancy on the woman or the fetus

Keywords: Gestational Diabetes, Dysthyroidism, Oxidative stress, Drugs therapy, Pregnancy

Drug Discovery, 2020, 14(33), 112-118

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