Volume 14, Issue 33, January - June, 2020

An innovative floating gastro-retentive drug system: Design, formulation and in vitro evaluation

Kanaka Durga Devi N^1♦, Arun Y¹, Narasimha Rao N², Nikhitha P¹, Hemalatha B³

¹K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, INDIA
²Orchid Healthcare, Irungattukottai, Sriperumbudur-602105, INDIA
³National Institute of Pharmaceutical Education And Research, Hyderabad-500037, INDIA

^♦Corresponding author
Dr.N.Kanaka Durga Devi, K.V.S.R Siddhartha college of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, INDIA; E-mail: nelluriss@rediffmail.com

ABSTRACT

The rationale of this research was to formulate and evaluate a gastro-retentive floating drug delivery system of Baclofen. Sustained release gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of the drug that is characterized by narrow absorption window and short half-life. Floating tablets of Baclofen were prepared by effervescent approach by using sodium bicarbonate as the gas forming agent and hydrophilic matrix forming polymers like HPMC K4M, HPMC K15M, HPMC K100M, Polyethylene oxide WSR-301,Polyethylene oxide WSR- 303 and Xanthan, guar gum. Direct compression technique was employed for the preparation of tablets. The prepared tablets were evaluated in terms of their pre-compression parameters (before compression), physical appearance, hardness, friability, weight variation, content uniformity, in-vitro buoyancy and in-vitro drug release. The optimized formulation (F12) containing xanthan gum40% and sodium bicarbonate-12.5% sustained the drug release (98.47±0.71%) upto 24 h and remained buoyant for 24 h with a floating lag time of 20.33±6.03 seconds. The optimized formulation (F12) was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominantly non-fickian (anomalous) diffusion. Optimized formulation (F12) showed no significant change in physical appearance, drug content, floating properties and drug release after storage at 40°C/75% RH for three months. Finally the formulation was found to be economical and may overcome the draw backs associated with the drug during its absorption

Keywords: Salbutamol, disintegrants, Pleurotus tuber-regium, FDTs

Drug Discovery, 2020, 14(33), 71-79

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