Volume 14, Issue 33, January - June, 2020

Studies on structural and biological aspects of transition metal complexes of the ligand 2- Amino -4-(P-Hydroxy Phenyl) Thiazole

Dinkar Malik^1♦, Punam Yadav¹, Sandeep Kumar¹, Vijai Malik²

¹Department of Chemistry, M. S. College, Saharanpur U.P. India
²Department of Botany, M. S. College, Saharanpur U.P. India

^♦Corresponding author
Dr. Dinkar Malik c/o Vijai Malik, 21-Mohit Vihar New Madhonagar Saharanpur-247001 (U.P) Email: dinkar_malik@rediffmail.com

ABSTRACT

Metal complexes of the type ML2X2 (where M = Cu (II), Co (II) and Ni (II), L= 2-amino-4-(p-hydroxy phenyl)thiazole and X= cl- , CH3COO- ) were prepared and characterized with the help of their elemental analysis, IR, electronic and magnetic susceptibility studies. IR studies have shown that nitrogen of the amino group and sulphur of the thiazole ring took part in co-ordination. Magnetic and electronic spectral studies have shown that all the complexes are having octahedral geometry. These newly synthesized complexes were also screened for their antifungal activity against different fungi at different concentrations. The activity decreases with decrease of concentration and the metal complexes are less toxic than the parent ligand.

Keywords: Thiazole, Fungicidal activity, Ligands

Drug Discovery, 2020, 14(33), 97-99

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