Volume 14, Issue 33, January - June, 2020

Optimization of a blend of natural and synthetic disintegrants in the formulation of fast disintegration tablets of Salbutamol

Yiobor Ogoh, Sylvester O Eraga, Magnus A Iwuagwu

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria

^♦Corresponding author
Sylvester O Eraga, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria. Tel: +2348030884928, Email: eragaso@uniben.edu

ABSTRACT

Fast disintegrating tablets are solid dosage forms that disintegrate rapidly without chewing upon contact with saliva in the oral cavity. The aim of the study was to formulate and evaluate fast disintegrating tablets of salbutamol using an optimized combination of disintegrants of natural and synthetic origin. A Box Behnken model was used to generate possible combinations and concentrations of Pleurotus tuber-regium powder, croscarmellose sodium and microcrystalline cellulose resulting in nine batches. Powder blends of the batches were slugged and broken down into granules. Flow parameters and drug-excipient interaction (Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FTIR)) analyses were carried out on the granules. Compressed tablets were evaluated for weight variation, friability, hardness, disintegration time, dissolution profiles and drug release kinetics. Granules gave Carr’s indices, Hausner’s ratios and angles of repose values ranging from 33-46 %, 1.51-1.87 and 26-30°, respectively, indicating good flow. Friability of the tablets ranged from 0.02-1.30 % while their hardness values was between 4.04- 5.16 kp and disintegration times < 30 sec. Dissolution profiles of the tablets showed over 60% salbutamol release within 5 min with the release most consistent with first order kinetics. DSC and FTIR studies showed no interaction between salbutamol and the formulation excipients. Fast disintegrating tablets of salbutamol with acceptable tablet properties was successfully produced using optimized concentrations of Pleurotus tuber-regium, croscarmellose sodium and microcrystalline cellulose. All the formulated tablets disintegrated within 30 sec with satisfactory hardness and dissolution profiles

Keywords: Salbutamol, disintegrants, Pleurotus tuber-regium, FDTs

Drug Discovery, 2020, 14(33), 61-70

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