Volume 14, Issue 33, January - June, 2020

Acute toxicity study on ARTHA GO capsules by using wistar rats

Manish P. Deshmukh¹, Sayali V. kathale^2♦, Ashish Budhrani¹, A.J. Anjankar¹

¹Dattameghe institute of medical sciences, Sawangi (Wardha)
²Vidyabharti College of pharmacy, Amravati

^♦Corresponding author
Miss sayali v. kathale, Deparment of pharmacology, Email ID - sayalikathale2205@gmail.com; Mb no – 8888460848

ABSTRACT

The aim of this study was to investigate the acute toxicity of ARTHA GO capsule using Wistar rat. Acute toxicity study was performed using OECD guidelines 421, a dose of (5mg/kg, 50mg/kg, 300mg/kg or 2000mg/kg) body weight administered orally to rats. In this study daily for 14 days animals were observed for toxic symptoms and mortality are subjected to necropsy; the animals which are intercurrently scarified also the one survive until the end of test are subjected to necropsy. Change in body weight, water intake, food intake as well as cage side observation were observed and reported in this study. The result of this acute toxicity study neither signs of toxicity nor mortality among the rats were observed of the experimental period. The overall this acute toxicity study indicates that ARTHA GO capsules is non-toxic up to a dose of 2000mg/kg body weight, which could be considered a safe dose.

Keywords: herbal formulation, inflammation, acute toxicity, capsule, arthritis, ARTHA GO

Drug Discovery, 2020, 14(33), 106-111

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