Volume 14, Issue 33, January - June, 2020

Anti-inflammatory activity of the methanol leaf extract and fractions of Lannea barteri Oliv. Engl. (Anacardiaceae) in rats

Mbaoji F.N, Peter I.E^♦, Onwuka A.M

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, PMB 410001, Enugu State, Nigeria

^♦Corresponding author
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. Email: ikechukwu.peter@unn.edu.ng

ABSTRACT

The L. barteri leaf extract and fractions were assessed for their anti-inflammatory potentials. The extract (200 and 400 mg/kg) and fractions (400 mg/kg)were employed in egg albumin-induced edema while 3% Tween 80 and piroxicam (50 mg/kg) served as negative and positive controls respectively. In xylene induced ear edema, 100 mg/ear of the extract, fractions and piroxicam was used while 3% Tween 80 served as the negative control. In cotton pellet-induced granuloma, 200 and 400 mg/kg extract and fractions, diclofenac 4 mg/kg and 3% Tween 80 were used. The HFLB caused the highest (40%) edema reduction at 3rd hour while 200 mg/kg ME caused the highest (28%) reduction at the 5th hour egg albumin-induced edema. There were significant (p<0.05) reduction of ear edema induced by xylene across the various groups compared to control. The HFLB caused the highest significant (p<0.01) percentage reduction (42.59%) of the granuloma tissue formed when compared to control. This study established that the methanol leaf extract and fractions of L. barteri reduce inflammation validating the folkloric use of L. barteri for the treatment inflammation and pain

Keywords: Anti-inflammatory activity, Egg albumin, Granuloma, Lannea barteri, Piroxicam

Drug Discovery, 2020, 14(33), 25-32

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