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Volume 15, Issue 35, 2021

About the Cover

Probiotics are usually used in functional foods due to their nutraceutical effects. But before using a strain to formulate functional foods, many tests have to be done to check some probiotic properties. Lactococcus lactis sp (L. lactis sp) strain isolated from fermented maize beverage “Sha’a” used in this study was grown in M17 broth for 56 h to determine the growth curve. Tolerance to the extreme gastrointestinal conditions (pH 2.0 and bile tolerance to 3.0%) was studied after gradual adaptation of the culture. Antibiotic resistance and antioxidant activity were evaluated. The ability to inhibit the growth of harmful bacteria was also checked. Results showed that culture strain could resist pH 2.0 and 3% bile for 24 hours. L. lactis sp. was able to produce acid which decreased the pH of the medium. Higher antioxidant activity was observed after 18 h of incubation (47.76 ± 0.00%). The strain was susceptible of most the antibiotics tested. Cultures presented a strong inhibition activity against the food-borne pathogens tested (Citrobacter sp., Shigella sp., Shigella dysenteriae, Enterococcus feacalis, and Pseudomonas sp.).


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ANALYSIS

A pimarane diterpene from Juniper servaschanica inhibits growth of Ovarian and Breast Cancer Cells

Sadri Abdullah Said, Yahya Tamimi, Afaf Mohd Weli, Md Sohail Akhtar

In our ongoing search for anticancer compounds from natural products we chromatographed cytotoxic active extracts from medicinal plants growing in Omanin order to isolate their active ingredients

Drug Discovery, 2021, 15(35), 1-5

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REVIEW

A novel and Emerging Coronavirus Infection: Repurposing and Scale of Advances of Therapeutics, Immunotherapeutics and Vaccine Development

Tapas Kumar Mohapatra, Reena Rani Nayak, Arijit Mondal, Sitansu Sekhar Nanda

A new coronavirus (nCOVID-19) has appeared in China for the first time, inducing various effects in humans and strongly linked to those induced by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome)

Drug Discovery, 2021, 15(35), 06-33

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RESEARCH

Ameliorative effect of a multi-nutrient-rich product against cyanide induced hepatorenotoxicity

Ilesanmi O. Babatunde, Asaba Abigai

The present study was designed to investigate the protective effects of trevo, on potassium cyanide-induced hepato- and nephrotoxicity in male Wistar rats

Drug Discovery, 2021, 15(35), 34-42

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REPORT

A novel validated method for estimation of Carbachol in ophthalmic preparations by spectrophotometer

Abdul Munan, Akhtar Jamal Khan, Mahwash Khan, Abdul Haleem, Muhammad Ishaq Nazeer

A simple and selective novel spectrophotometric method has been proposed for determination of Carbachol in pure and pharmaceutical ophthalmic preparations. The method is developed on formation of ion-pair complex between Bromophenol blue (BPB) and Carbachol (Carb), which is blue in color

Drug Discovery, 2021, 15(35), 43-51

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RESEARCH

Effects of Novel Silver (I) NHeterocyclic Carbene Complexes on Mycotoxin Producing Fungi and Biofilm Forming Microorganisms

Esin Poyrazoğlu Çoban, Engin Ertuğrul, Rukiye Fırıncı, Halil Bıyık, Muhammet Emin Günay

Ag (I) complexes were prepared for a series of NHC substituents. Firstly, NHC precursors (1-9) were synthesized. In the second step, Ag (I) -NHC complexes (10-15) were synthesized. Structure of silver (I) N-heterocyclic carbene complexes was analysed using 1H- and 13C-NMR spectroscopy

Drug Discovery, 2021, 15(35), 52-62

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ANALYSIS

Assessment of compliance with anti tuberculosis drug treatment among patients with tuberculosis in Sokoto south local Government area of Sokoto state Nigeria

Sulaiman Aliyu, Yusuf Sarkingobir, Bahira BY, Tambari BM, Aminu N, Abubakar Alh. Tambuwal

The study employed quantitative descriptive study design to examine patients’ compliance to Anti TB treatment among TB patients in Sokoto south local government Area of Sokoto Nigeria. T

Drug Discovery, 2021, 15(35), 63-70

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Evaluation of probiotic potentials of Lactococcus lactis sp. and its antimicrobial activity against some foodborne pathogens

Dangang BDS, Zambou NF, Agrawal R, Fonteh AF

Probiotics are usually used in functional foods due to their nutraceutical effects. But before using a strain to formulate functional foods, many tests have to be done to check some probiotic properties

Drug Discovery, 2021, 15(35), 71-78

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REPORT

Impact of Administration of Diclofenac on Cardiac Biomarkers of Adult Male Albino Rats

Okwakpam FN, Abarikwu S, Monanu MO

Non- steroidal anti-inflammatory drugs (NSAIDs) such as Diclofenac are in common use worldwide for the treatment of conditions such as pain, rheumatoid arthritis, and musculoskeletal disorders

Drug Discovery, 2021, 15(35), 79-83

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ANALYSIS

Assessment of Antidepressant Profile of Methanolic extract of Areca catechu using Mice as an experimental Model

Mansour AS, Manchineni PR, Gunda RK

Purpose: The purpose of present investigation to assess the anti-depressant activity of methanolic extract of Areca catechu using Mice model

Drug Discovery, 2021, 15(35), 84-90

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Acute and Subchronic Toxicity Studies of Methanol Leaves Extract of Ficus Platyphylla on Albino Rats

Ukwuani-Kwaja AN, Sani I, Kindzeka LS

F. platyphylla is a tree that is native throughout the tropics with a few extending into the semi-warm temperate zone

Drug Discovery, 2021, 15(35), 91-97

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RESEARCH

Neuroleptic drug-induced hyperprolactinemia and associated neurochemical, hematological and histological changes in rats

Tiwari P, Sahu PK

The study aims to validate the dose of haloperidol (HPL) and sulpiride (SPD) needed to induce hyperprolactinemia in both male and female albino rats and to evaluate the neurochemical, hematological and histological changes in the anterior pituitary gland, adrenal gland, and spleen

Drug Discovery, 2021, 15(35), 98-107

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A novel method for preparation of Antibacterial and Atraumatical Surgical Sutures

Munan A, Khan AJ, Khan M, Abbas G, Khan S, Nazir MI, Fakhar-e-Alam, Iqbal A

To reduce some risk associated problems such as tissue trauma and surgical site infection a novel Atraumatical and anti-bacterial sutures were developed by silicon and triclosan mixed coating

Drug Discovery, 2021, 15(35), 108-115

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REPORT

Synthesis of 2-(1Himidazo[4,5-b]pyridin-2-ylimino)-5- arylidenethiazolidin-4-ones,1-(1H-imidazo[4,5- b]pyridin-2-yl)-5-methyl-3-aryl-1,3,5-triazinane-2- thiones and 3-(1H-imidazo[4,5-b]pyridin-2-yl)-5-aryl1,3,5-oxadiazinane-4-thiones

Dayakar G, Jeyanthi A, Kalyani T

1H-imidazo[4,5-b]pyridin-2-amine (1) reacts with ammoniumthiocyanide to form 1-(1H-imidazo[4,5-b]pyridin-2-yl)thiourea (2), which on reaction with chloroacetic acid gives 2-(1H-imidazo[4,5-b]pyridin-2-ylimino)thiazolidin-4- one

Drug Discovery, 2021, 15(35), 116-121

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© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution License 4.0 (CC BY 4.0).