Volume 15, Issue 35, 2021

About the Cover

In our ongoing search for anticancer compounds from natural products we chromatographed cytotoxic active extracts from medicinal plants growing in Omanin order to isolate their active ingredients. We hereby report isolation of a cytotoxic pimarane diterpenoid, 3-hydroxy-ent-pimara8(14),15-dien-19-oic acid (1) from hexane extract of Juniperus servaschanica collected from Oman. The anticancer property was evaluated against ovarian (MCAS) and breast (MDA MB231) cancer cell lines by Alamar-blue assay. Compound 1 was active against both ovarian and breast cancer cells (IC50 = 24.16 and 16.13 µg/ml, respectively). Additionally, the molecule showed little damaging effect against non-cancerous cells, fibroblast at its IC50 dosage. Further investigation on this metabolite and its derivatives might lead to discovery of new chemical entities for control of cancer.

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ANALYSIS

A pimarane diterpene from Juniper servaschanica inhibits growth of Ovarian and Breast Cancer Cells

Sadri Abdullah Said, Yahya Tamimi, Afaf Mohd Weli, Md Sohail Akhtar

In our ongoing search for anticancer compounds from natural products we chromatographed cytotoxic active extracts from medicinal plants growing in Omanin order to isolate their active ingredients

Drug Discovery, 2021, 15(35), 1-5

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Development and Characterization of Tolvaptan HCl Fast Dissolving Tablets

Raghavendra Kumar Gunda, Prasada Rao Manchineni, Rajini Sudireddy

Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Tolvaptan HCl. Tolvaptan HCl, a newer aquaretic sorvaptan

Drug Discovery, 2021, 15(35), 6-15

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REPORT

Isolation, cloning and transformation of glucan binding protein (GBP) gene

Ravikumar Patil HS, Vasantha Naik T, Vijay Avin BR, Sayeswara HA

This work was to isolate the glucan binding protein (gbp) gene from Streptococcus mutans, it possesses at least four glucan binding proteins GbpA, GbpB, GbpC, and GbpD, each of which appears to be immunologically and biochemically distinct using various processes

Drug Discovery, 2021, 15(35), 16-22

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REVIEW

A novel and Emerging Coronavirus Infection: Repurposing and Scale of Advances of Therapeutics, Imunotherapeutics and Vaccine Development

Tapas Kumar Mohapatra, Reena Rani Nayak, Arijit Mondal, Sitansu Sekhar Nanda

A new coronavirus (nCOVID-19) has appeared in China for the first time, inducing various effects in humans and strongly linked to those induced by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome)

Drug Discovery, 2021, 15(35), 23-50

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RESEARCH

Ameliorative effect of a multi-nutrient-rich product against cyanide induced hepatorenotoxicity

Ilesanmi O. Babatunde, Asaba Abigai

The present study was designed to investigate the protective effects of trevo, on potassium cyanide-induced hepato- and nephrotoxicity in male Wistar rats

Drug Discovery, 2021, 15(35), 51-59

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REPORT

A novel validated method for estimation of Carbachol in ophthalmic preparations by spectrophotometer

Abdul Munan, Akhtar Jamal Khan, Mahwash Khan, Abdul Haleem, Muhammad Ishaq Nazeer

A simple and selective novel spectrophotometric method has been proposed for determination of Carbachol in pure and pharmaceutical ophthalmic preparations. The method is developed on formation of ion-pair complex between Bromophenol blue (BPB) and Carbachol (Carb), which is blue in color

Drug Discovery, 2021, 15(35), 60-68

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RESEARCH

Effects of Novel Silver (I) NHeterocyclic Carbene Complexes on Mycotoxin Producing Fungi and Biofilm Forming Microorganisms

Esin Poyrazoğlu Çoban, Engin Ertuğrul, Rukiye Fırıncı, Halil Bıyık, Muhammet Emin Günay

Ag (I) complexes were prepared for a series of NHC substituents. Firstly, NHC precursors (1-9) were synthesized. In the second step, Ag (I) -NHC complexes (10-15) were synthesized. Structure of silver (I) N-heterocyclic carbene complexes was analysed using 1H- and 13C-NMR spectroscopy

Drug Discovery, 2021, 15(35), 69-79

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ANALYSIS

Assessment of compliance with anti tuberculosis drug treatment among patients with tuberculosis in Sokoto south local Government area of Sokoto state Nigeria

Sulaiman Aliyu, Yusuf Sarkingobir, Bahira BY, Tambari BM, Aminu N, Abubakar Alh. Tambuwal

The study employed quantitative descriptive study design to examine patients’ compliance to Anti TB treatment among TB patients in Sokoto south local government Area of Sokoto Nigeria. T

Drug Discovery, 2021, 15(35), 80-87

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Hepatoprotective activity of Andrographis paniculata on lipid peroxidase, antioxidant enzymes and liver enzymes in Thioacetamide intoxicated rats

Anitha P, Jai kumar S, Devaki T

The efficacy of Andrographis paniculata (AP) extract was studied on thioacetamide induced hepatic damage in rats.

Drug Discovery, 2021, 15(35), 88-94

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Evaluation of probiotic potentials of Lactococcus lactis sp. and its antimicrobial activity against some foodborne pathogens

Dangang BDS, Zambou NF, Agrawal R, Fonteh AF

Probiotics are usually used in functional foods due to their nutraceutical effects. But before using a strain to formulate functional foods, many tests have to be done to check some probiotic properties

Drug Discovery, 2021, 15(35), 95-102

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Impact of Administration of Diclofenac on Cardiac Biomarkers of Adult Male Albino Rats

Okwakpam FN, Abarikwu S, Monanu MO

Non- steroidal anti-inflammatory drugs (NSAIDs) such as Diclofenac are in common use worldwide for the treatment of conditions such as pain, rheumatoid arthritis, and musculoskeletal disorders

Drug Discovery, 2021, 15(35), 103-107

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Assessment of Antidepressant Profile of Methanolic extract of Areca catechu using Mice as an experimental Model

Mansour AS, Manchineni PR, Gunda RK

Purpose: The purpose of present investigation to assess the anti-depressant activity of methanolic extract of Areca catechu using Mice model

Drug Discovery, 2021, 15(35), 108-114

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Acute and Subchronic Toxicity Studies of Methanol Leaves Extract of Ficus Platyphylla on Albino Rats

Ukwuani-Kwaja AN, Sani I, Kindzeka LS

F. platyphylla is a tree that is native throughout the tropics with a few extending into the semi-warm temperate zone

Drug Discovery, 2021, 15(35), 115-121

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RESEARCH

Neuroleptic drug-induced hyperprolactinemia and associated neurochemical, hematological and histological changes in rats

Tiwari P, Sahu PK

The study aims to validate the dose of haloperidol (HPL) and sulpiride (SPD) needed to induce hyperprolactinemia in both male and female albino rats and to evaluate the neurochemical, hematological and histological changes in the anterior pituitary gland, adrenal gland, and spleen

Drug Discovery, 2021, 15(35), 122-131

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A novel method for preparation of Antibacterial and Atraumatical Surgical Sutures

Munan A, Khan AJ, Khan M, Abbas G, Khan S, Nazir MI, Fakhar-e-Alam, Iqbal A

To reduce some risk associated problems such as tissue trauma and surgical site infection a novel Atraumatical and anti-bacterial sutures were developed by silicon and triclosan mixed coating

Drug Discovery, 2021, 15(35), 132-139

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ANALYSIS

Synergistic effects of Chitin & Chitosan derived from shrimp waste with commercial antibiotics against Streptococcus Mutans

Elizabeth Rani C, Vinoth M, Arunkumar S

The present study was intended to find out novel drug formulations of commercial antibiotics using chitin and chitosan against an oral pathogen Streptococcus mutans.

Drug Discovery, 2021, 15(35), 140-153

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REPORT

Synthesis of 2-(1Himidazo[4,5-b]pyridin-2-ylimino)-5- arylidenethiazolidin-4-ones,1-(1H-imidazo[4,5- b]pyridin-2-yl)-5-methyl-3-aryl-1,3,5-triazinane-2- thiones and 3-(1H-imidazo[4,5-b]pyridin-2-yl)-5-aryl1,3,5-oxadiazinane-4-thiones

Dayakar G, Jeyanthi A, Kalyani T

1H-imidazo[4,5-b]pyridin-2-amine (1) reacts with ammoniumthiocyanide to form 1-(1H-imidazo[4,5-b]pyridin-2-yl)thiourea (2), which on reaction with chloroacetic acid gives 2-(1H-imidazo[4,5-b]pyridin-2-ylimino)thiazolidin-4- one

Drug Discovery, 2021, 15(35), 154-159

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ANALYSIS

Antimicrobial effect of the microcurrent application after burns of 2° degree induced in the skin of the back in wistar mice (Novergicus rattus)

Angeloti PF, Santos GMT, Mendonça FAS, Levada MMO, Beretta ALRZ

Many studies are demonstrating the therapeutic use through electric incentives in countless processes of tissue repair. Initially the skin harmed by burn becomes sterile.

Drug Discovery, 2021, 15(35), 160-164

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