Volume 15, Issue 35, January - June, 2021

Ameliorative effect of a multi-nutrient-rich product against cyanide induced hepatorenotoxicity

Ilesanmi O. Babatunde^♦, Asaba Abigai

Department of Biochemistry, Faculty of Science, Federal University, Otuoke, Bayelsa State, Nigeria

^♦Corresponding author
Department of Biochemistry, Faculty of Science, Federal University, Otuoke, Bayelsa State, Nigeria; Email: ilesanmiob@fuotuoke.edu.ng

ABSTRACT

The present study was designed to investigate the protective effects of trevo, on potassium cyanide-induced hepato- and nephrotoxicity in male Wistar rats. Rats received Trévo (2 ml) after cyanide (0.5 mg/kg) exposure. Twenty-four hours after last administration rats were sacrificed and blood, liver and kidney tissues collected for haematological (neutrophils, lymphocytes, monocytes, eosinophils, basophils, white blood cells (WBC) and parked cell volume (PCV)), biochemical and histological assays. Our results shows that trevo significantly reverse the increased activity of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) induced by cyanide while it had no significant effect on aspartate aminotransferase (AST) induced increased (P<0.05) at the various time of trevo administration. Trevo also significantly decrease the concentration of urea as compared to cyanide group while it caused an insignificant effect in creatinine concentration in comparison to cyanide only group. The alteration in all the hematological parameters analysed caused by cyanide was significantly reversed by treatment with trevo (P<0.05) at the various time of administration. Histology showed that cyanide caused pathological lesion in the hepatocyte as observed with increased bile deposition and fatty droplets and reduction in hepatocyte density which was reversed by treatment with trevo. In the nephrocyte, cyanide caused no pathological lesion in the kidney tissue, neither did administration of trevo had any pathological effect. The reversal of cyanide-induced hepato- and nephrotoxicity by trevo, shows that it can be administered as an antidote against cyanide exposure, especially when administered immediately after cyanide poison

Keywords: nCOVID-19; Vaccine; Therapeutics

Drug Discovery, 2021, 15(35), 51-59

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