Volume 15, Issue 35, January - June, 2021

Effects of Novel Silver (I) NHeterocyclic Carbene Complexes on Mycotoxin Producing Fungi and Biofilm Forming Microorganisms

Esin Poyrazoğlu Çoban^1♦, Engin Ertuğrul², Rukiye Fırıncı², Halil Bıyık¹, Muhammet Emin Günay²

¹Department of Biological Sciences, Faculty of Arts and Sciences, Adnan Menderes University, Aydın, Turkey
²Department of Chemistry, Faculty of Arts and Sciences, Adnan Menderes University, Aydın, Turkey

^♦Corresponding author
Esin Poyrazoğlu Çoban, Faculty of Arts and Sciences, Adnan Menderes University, Aydın, Turkey, Phone +90 256 2182000, Email: epoyrazoglu@adu.edu.tr, Orcid id: 0000-0002-3921-5362

ABSTRACT

Ag (I) complexes were prepared for a series of NHC substituents. Firstly, NHC precursors (1-9) were synthesized. In the second step, Ag (I) -NHC complexes (10-15) were synthesized. Structure of silver (I) N-heterocyclic carbene complexes was analysed using 1H- and 13C-NMR spectroscopy. The activity of synthesized and characterized silver complexes on mycotoxin producing fungi and biofilm-forming Gram negative or positive bacteria and Candida albicans was investigated. As a result, it was determined that the most effective compound was 14, 15 and 13 respectively. Especially, compound 14 has been shown to have a high effect (12- 15mm/16-64µgmL-1) against Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 35032, Listeria monocytogenes ATCC 19112, Candida albicans ATCC 10231, Aspergillus parasiticus NRLL 502. The results of antimicrobial activity and microfungus micelle development were also found to be compatible

Keywords: Silver (I) N-Heterocyclic Carbene Complexes, Mycotoxin, Fungi, Biofilm, Microorganisms

Drug Discovery, 2021, 15(35), 52-62

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