Volume 15, Issue 35, January - June, 2021

Acute and Subchronic Toxicity Studies of Methanol Leaves Extract of Ficus Platyphylla on Albino Rats

Ukwuani-Kwaja AN, Sani I, Kindzeka LS^♦

Department of Biochemistry, Faculty of Life Science, Kebbi State University of Science and Technology Aliero, Kebbi State, Nigeria

^♦Corresponding author
Kindzeka, Lesley Sahber Cell Phone Number: +2348037423522 Email: kinleslo@gmail.com Department of Biochemistry, Faculty of Life Science, Kebbi State University of Science and Technology Aliero, Kebbi State, Nigeria

ABSTRACT

F. platyphylla is a tree that is native throughout the tropics with a few extending into the semi-warm temperate zone. In Nigeria, it is predominant in the Northern regions of the country. Acute oral toxicity (LD50) was determined using five (5) rats and monitored for fourteen while twenty five (25) rats were used for the subchronic toxicity studies. They were grouped into five groups and treated daily with the extract orally for 28 days. The estimated LD50 was found to be greater than 3000mg/kg body weight as no mortality was recorded during the 14 days observation period. The biochemical indices of the kidney and liver on different doses of the extract were not significantly different (P>0.05) except for creatinine, ALT and AST which showed significant decrease (P˂0.05) when compared to control. However, haematological parameters such as WBC and PLT were also significantly increased (P˂0.05) compared to the control. The findings reveal F. platyphylla may be potentially safe for consumption.

Keywords: Ficus Platyphylla, Acute Toxicity, Subchronic Toxicity, Albino Rat

Drug Discovery, 2021, 15(35), 91-97

PDF