Volume 15, Issue 35, January - June, 2021

Hepatoprotective activity of Andrographis paniculata on lipid peroxidase, antioxidant enzymes and liver enzymes in Thioacetamide intoxicated rats

Anitha P^1♦, Jai kumar S², Devaki T²

¹Dept of Biochemistry & Bioinformatics, Hindustan College of Arts & Science, Rajiv Gandhi Salai (OMR), Kelambakkam, Padur, Chennai -603103, Tamil Nadu, India
²Department of Biochemistry, University of Madras, Guindy campus, Chennai-600025, Tamil Nadu, India

^♦Corresponding author
Anitha P, Dept of Biochemistry & Bioinformatics, Hindustan College of Arts & Science, Rajiv Gandhi Salai (OMR), Kelambakkam, Padur, Chennai -603103, Tamil Nadu, India, E-mail: anitha123raja@gmail.com

ABSTRACT

The study employed quantitative descriptive study design to examine patients’ compliance to Anti TB treatment among TB patients in Sokoto south local government Area of Sokoto Nigeria. The results were determined. 44.00% of the respondents were single, and 50% married, while 3.30% was divorced and widow with the least percentage of 2.70%. 58% of the respondent’s ages 10-70 years were males and 42% age -10-70 years were females. The knowledge and understanding of TB was categorized into two: 78% of the respondents show highest percentage of 78% with no knowledge and understanding of TB while only 22% among them with the knowledge and understanding of TB. It was found that, 76.66% of the respondents aged 10-70 years complete the treatment and 23.33% of the respondents aged 10-70 years did not comply with the treatment. 36% of the respondents were aware of the implication of untreated TB, while 64% of the respondents were unaware of the implication of untreated TB. 46.70% of the respondents aged 10-70 years have none income, 24.70% aged 10-70 years have 5000-8000, while 14.00% of the respondents aged 10-70 years had 8000 and above. Employment assessment shows that 39.30% of the respondents were unemployed, 16.00% employed, 16.00% business people, 34. 00% of the respondents were students and 4.70% were farmers. 2.00% of the respondents had no education, 48.70% of the respondents had education and 10.0% of the respondents had tertiary education. All the respondents 100% are aware of free Anti-TB treatment printed by government of Sokoto State. 80% of the respondents collect their medications at designated centers in the clinics. Only 20% of the respondents collect from the Hospitals. It was revealed that, 92% of the respondents ware far away from the DOT designated centres, only 8% of the respondents are close to the centers in Sokoto state. Shows that 89.33% of the respondents’ mode of transport was public transport, 8% travelled by foot and only 2.66% visit health facilities through their own transport system, possibly vehicles, motorcycle or bicycler. 60% of the respondents take their medication in the morning, 24% in the afternoon, while 13% take their medication in the evening time and only 2.66% at bed time. 96.66% of the respondents take their medication after eat food 3.33% with food. 76.66 of the respondents were reminded on taking medications by their family members, 22% by visibility of the medication and only 1.33% is reminded by DOT supporter and no response for other category. Shows that 76.66% of the respondents did not missed taking medications within the last 7 days; only 23.33% missed their medications with last 7 days. Conclusively, majority of the respondents complied to Tb therapy.

Keywords: Andrographis paniculata; Hepatoprotective; Thioacetamide

Drug Discovery, 2021, 15(35), 88-94

PDF