Volume 15, Issue 35, January - June, 2021

Assessment of Antidepressant Profile of Methanolic extract of Areca catechu using Mice as an experimental Model

Mansour AS¹, Manchineni PR², Gunda RK^3♦

¹Research Scholar, Department of Pharmacology, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India; 522601.
²Professor cum Principal, Department of Pharmaceutical Analysis, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.
³Assistant Professor, Department of Pharmaceutics, M.A.M college of Pharmacy, Kesanupalli (V), Narasaraopet, Guntur (Dt), Andhra Pradesh, India; 522601.

^♦Corresponding author
Dr. Raghavendra Kumar Gunda; M.Pharm.,Ph.D Assistant Professor, Department of Pharmaceutics, MA.M college of Pharmacy, Kesanupalli (V) Narasaraopet, Guntur(D.t), A.P. India-522601. E-mail: raghav.gunda@gmail.com, Researcher id: G-5095-2015, Orcid id : 0000-0002-4271- 8614, Mob: +91-9666705894.

ABSTRACT

Purpose: The purpose of present investigation to assess the anti-depressant activity of methanolic extract of Areca catechu using Mice model. Methods: The methanolic extract was prepared using cold extraction process with the help of continuous hot percolator apparatus. The final extract was evaluated for preliminary phytochemical analysis, acute toxicological studies (Mice Model). Anti-depressant assessment was carried out as per the standard methods i.e forced swimming test, tail suspension test, 5-HT induced head twitches in mice, clonidine induced aggression, L-dopa induced hyper activity and aggressive behavior test. Results: Results reveals that extract possess good antidepressant potential. By observing significant change in the immobility (reduced immobility) for both forced swimming test as well tail suspension test it confirms the antidepressant effect for Areca catechu methanolic extract. Conclusion: Methanolic extract of Areca catechu having potential antidepressant profile. Further continuing research is needed to determine constituents, those having antidepressant activity for the safe and effective use in human welfare.

Keywords: Methanolic extract, areca catechu, mice, immobility, tail suspension test, forced swimming

Drug Discovery, 2021, 15(35), 108-114

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