ARTICLE
Relationship between cyanide poisoning in cassava effluent and epididymis of Albino Wistar rats
Gabriel Donatus Edem, Akpan Udo Ekanem, Eno Uwah Ettetor, Onome Gabriel Ahorituwere
The epididymis is primarily known for temporary storage and development of sperm to maturation. Cassava effluent (Garri and Fufu effluent) contains many antinutrients such as cyanide. This research was conducted to investigate the relationship between cyanide poisoning in cassava effluent and the epididymis of Wistar rats
Drug Discovery, 2025, 19(43), e1dd2013
Abstract | PDF
Investigating the effect of Centella Asiatica on placenta and pregnancy outcome in rat experimental model
Akporobo Ejeguo, Christopher Lucky Sakpa
Plant research and use for purposes other than food has been available for thousands of years. Such use includes the treatment of diseases and illnesses as well as for dermatological purposes. Traditionally, several specific ailments have been cured with different parts of medicinal plants
Drug Discovery, 2025, 19(43), e2dd2017
Abstract | PDF
Synthesis, characterization, anticancer, and antioxidant studies of new azo-Schiff compounds derived from 2-naphthol
Mariam Alwan Abdulridua, Hussein Ali Hussein ALSa’idy, Ali Esmail Al-Snafi
Two new 2-naphthol-thiazole-azo compound Schiff bases of potential antitumor and/or antioxidant influences were chemically synthesized. The synthesized Schiff bases structures were identified using elemental analysis (CHN), mass spectroscopy, Fourier transform infrared FTIR & 1HNMR spectral techniques
Drug Discovery, 2025, 19(43), e3dd2037
Abstract | PDF
Spermatogenic effect of myricetin on ethyl-alcohol induced sperm toxicity in pre-pubertal male Wistar rats
Emeka Godson Anyanwu, Ikanna Ekanem Asuquo, Daniel Itiza Akaahan
Consistent ethanol beverage exposure adversely affects male reproductive function by oxidative stress-related mechanisms. This study was designed to investigate the spermatogenic and spermiographic effects of myricetin on ethyl-alcohol-induced sperm toxicity in pre-pubertal male Wistar rats
Drug Discovery, 2025, 19(43), e4dd2041
Abstract | PDF
Propoxazepam drug-drug interaction, mediated by cytochrome 450 2d6 (preclinical in vitro data)
Mykola Golovenko, Iryna Valivodz, Anatoliy Reder, Vitalii Larionov
The relevance of this study is the need to study potential drug interactions of the new analgesic propoxazepam, which belongs to the benzodiazepine group. Benzodiazepines are widely used for their anxiolytic and analgesic properties, and understanding their metabolic interactions is critical for safe clinical use.
Drug Discovery, 2025, 19(43), e5dd2047
Abstract | PDF
Study of the chemical composition of the plant leaves of the Salicornia europaea L. plant spread along the Syrian coast adjacent to the Mediterranean Sea
Ola Shakohi, Hussam Eddin Laika, Abeer Sultan, Hitham Hasan
Salicornia europaea L. is an annual halophyte adapted to saline coastal environments, valued as a food source and in traditional medicine for its antioxidant and antiinflammatory properties.
Drug Discovery, 2025, 19(43), e6dd2049
Abstract | PDF
Orally Disintegrating Film formulation of standardized extract of red ginger (Zingiber officinale var. Rubrum)
Febriyenti, Rizki Siti Aisyah, Rahima Intan, Mursal Azizah, Kumalasari Charrisca Syahyuning, Susanti Meri
Red ginger (Zingiber officinale var. Rubrum) is a biopharmaceutical plant that contains 6-gingerol, 6-shogaol, and galanolactone. The preparation of red ginger in traditionally allowed its development. One of them is making it into Oral Disintegrating Films (ODFs).
Drug Discovery, 2025, 19(43), e7dd2051
Abstract | PDF
Preliminary Standardization and Antifungal Potential of the Ethanol Extract of Emilia praetermissa leaf on Candida albicans and Aspergillus niger
Lawrence U Nwankwo, Christiana O Akpo, Uyoyo M Ukpe
Fungal infections caused by Candida albicans and Aspergillus niger has become a rampant global health challenge, particularly among immunosuppressed individuals
Drug Discovery, 2025, 19(43), e8dd2063
Abstract | PDF
Acute and Subchronic Toxicity Evaluation of Ficus thonningii Leaves Hexane Extract in Albino Rats
Nwaogu Jude, Sanusi Ahmad Jega, Tijjani Nasir
Medicinal plant has a significant contribution in providing knowledge to the researchers in the field of ethnobotany and ethnopharmacology, However, toxicological studies contribute significantly to human health
Drug Discovery, 2025, 19(43), e9dd2067
Abstract | PDF
Assessment of the Yemeni Herbal Formulations containing Azadirachta indica Leaves Extract as a Wound Healing
Ali A Al-Mehdar, Ali Salman Al-Shami, Saber Mohammed Haroon
Background: Azadirachta indica, resemble as the neem plant, which used as alternative therapy in Asia as well as Africa, known for its antibacterial, antifungal, and antiinflammatory properties as its rich in biologically active compounds can be used as wound healing
Drug Discovery, 2025, 19(43), e10dd2071
Abstract | PDF
Tabletability and sperm boosting properties of Allium sativum (garlic), Tetracarpidium conophorum (walnut) and Cyperus esculentus (tiger nut) powders
Ayotomiwa Ashiru, Oladapo Adetunji, Oludele Itiola
Decoctions made with garlic, walnut and tiger nut powders have been used to treat male infertility. In this study, the powders were characterized, formulated into tablets and assessed for their efficacy in treating male infertility
Drug Discovery, 2025, 19(43), e11dd2073
Abstract | PDF
Molecular Docking and Pharmacokinetic studies of bioactive compounds from methanolic leaf extracts of Allium hookeri against alpha amylase & alpha glucosidase
Deepti Teotia, Vijai Malik
Alpha-glucosidase and alpha-amylase inhibitors are widely used oral medication for diabetes. These manage the breakdown of carbohydrates into simple sugars, which are then absorbed by the intestines
