Volume 19, Issue 43, January - June, 2025

Orally Disintegrating Film formulation of standardized extract of red ginger (Zingiber officinale var. Rubrum)

Febriyenti^♦, Rizki Siti Aisyah, Rahima Intan, Mursal Azizah, Kumalasari Charrisca Syahyuning, Susanti Meri

Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163, West Sumatera, Indonesia

^♦Corresponding author
Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang 25163, West Sumatera, Indonesia

ABSTRACT

Red ginger (Zingiber officinale var. Rubrum) is a biopharmaceutical plant that contains 6-gingerol, 6-shogaol, and galanolactone. The preparation of red ginger in traditionally allowed its development. One of them is making it into Oral Disintegrating Films (ODFs). ODFs is a very thin film that will immediately disintegrate if placed on the tongue so it can provide a faster effect. This research aims to formulate red ginger extract as an ODF. Red ginger extract is used as an active ingredient. The polymers to be chosen are HPMC (Hydroxypropyl methylcellulose) K4M and HPMC E3. The plasticizers to be chosen are glycerin, polyethylene glycol (PEG 400), and Propylene glycol (PG). Sucrose is used as a sweetener agent and sodium benzoate as a preservative. The method we used for making ODFs is solvent casting. The evaluations of ODFs are organoleptic, weight measurement, film thickness, disintegration time, and swelling power. The results showed that the ODFs preparation of red ginger extract with 2% HPMC K4M and 30% PEG 400 from polymer formed a film that met the requirements. The weight of the film is 0.027 ± 0.003 g, the thickness of the film is 0.063 ± 0.008 mm, the disintegration time of the film using the petri dish method is 25.03 ± 2.41 seconds, with the frame method is 5.45 ± 0.39 seconds, and the swelling index in 10 seconds is 146.1 ± 4.7%.

Keywords: ODF, red ginger extract, HPMC K4M, PEG 400

Drug Discovery, 2025, 19(43), e7dd2051

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DOI: https://doi.org/10.54905/disssi.v19i43.e7dd2051

Published: 01 March 2025