Volume 19, Issue 43, January - June, 2025

Assessment of the Yemeni Herbal Formulations containing Azadirachta indica Leaves Extract as a Wound Healing

Ali A Al-Mehdar¹, Ali Salman Al-Shami^2♦, Saber Mohammed Haroon¹

¹Department of pharmacology, faculty of medicine, Thamar university, Thamar city, Yemen
²Department of pharmacology, faculty of medicine, Sanaa university, Sanaa city, Yemen

^♦Corresponding author
Dr. Ali Salman Al-Shami, Department of pharmacology, faculty of medicine, Sanaa university, Sanaa, Yemen

ABSTRACT

Background: Azadirachta indica, resemble as the neem plant, which used as alternative therapy in Asia as well as Africa, known for its antibacterial, antifungal, and antiinflammatory properties. as its rich in biologically active compounds can be used as wound healing. objective: to assess and compare the wound healing activity of neem leaves obtained from two different regions. Methodology: Neem leaves were collected, dried, and extracted using ethanol via a rotary evaporator. Phytochemical screening and microbial testing were conducted. Cream and gel formulations were prepared and evaluated for physical properties. The wound healing activity was assessed by applying these formulations to rabbits. Results: Azadirachta indica shows the availability of phenols, alkaloids, flavonoids, tannins, saponins, and glycosides. The extract exhibited antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli, as well as antifungal activity against Candida albicans. The cream formulations had appropriate pH and homogeneity. The application of the formulations on rabbits yielded positive and excellent wound healing results, surpassing those of standard and control treatments. Conclusion: The ethanolic extract of Azadirachta indica leaves exhibits powerful bactericidal and fungicidal properties, making it a useful agent for treating wounds and accelerating the healing process.

Keywords: Azadirachta indica, Wound Healing, Antibacterial, Yemeni Herbal Medicine

Drug Discovery, 2025, 19(43), e10dd2071

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DOI: https://doi.org/10.54905/disssi.v19i43.e10dd2071

Published: 07 June 2025