Volume 20, Issue 45, 2026 (Forthcoming Issue)

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Due to the limited metabolomic data of Artemisinin-Based Combination Therapies (ACTs) in endemic regions, the study assessed the metabolomics of recommended ACTs to understand the pattern of adverse effects in experimental animals (mice, rats, guinea pigs, rabbits) and humans using mass spectrometry. Malaria infection was simulated in all the animal models using Plasmodium berghei NK65, patients who had Plasmodium falciparum infection were also selected. ACTs were administered orally in conventional doses. Serum samples were collected and assayed for metabolomic parameters using standard protocols. The most common metabolites that were significantly altered metabolites in all the models were D-glucose, creatinine, glutamate, aspartate, glycine, taurine, eicosapentaeinoyl-glycerol, hexadecanoic acid, amino-butanoate, and L-tyrosine (OPLS-DA). Commonly altered pathways were lipid, amino acid, carbohydrate, and nucleotide (OPLS-DA).

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ARTICLE

Metabolomics of Artemisinin-Based Combination Therapies in experimental animals and humans

Sylvester Aghahowa, Raymond Ozolua, Enitome Bafor, Ambrose Isah, Michael Aghahowa, David Osifo, Philip Obarisiagbon, Paul Aikorogie

Due to the limited metabolomic data of Artemisinin-Based Combination Therapies (ACTs) in endemic regions, the study assessed the metabolomics of recommended ACTs to understand the pattern of adverse effects in experimental animals (mice, rats, guinea pigs, rabbits) and humans using mass spectrometry

Drug Discovery, 2026, 20(45), e1dd3033

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GC-MS and In-Silico Assessment of Orange Peel Phyto-compounds as Antimicrobial and Drug-Like Agents

Abalaka ME, Oloninefa SD, Attah F, Jagaba A

Plants are valuable sources for creating new medicines because they contain many natural compounds that can have positive health effects due to their secondary metabolites.

Drug Discovery, 2026, 20(45), e2dd3030

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Exploring In silico model to extrapolate the anti-diabetic potential of phytocompounds from Tapinanthus bangwensis in type 2- diabetes treatment

Godwin O Ihegboro, Chimaobi J Ononamadu, Jude Ezeh, Emmanuel C Okoye, Etoro-Abasi Ekanem, Chidimma H Aneke, Divine Imade, Princewwll Odo, Rosemary Jonathan, Hilary Oblia, Marvelous Offuna

The study used computational tools to predict the phytocompounds (Tapinanthus bangwensis) with potential to ameliorate Diabetes Mellitus. Firstly, two extracts was screened for inhibitory activity; α-amylase (α-A), and α-glucosidase (α-G), and antioxidant capacity

Drug Discovery, 2026, 20(45), e3dd3037

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Bioactivity-Guided Isolation and In Silico Molecular Studies of Anti Bitis arietans Venom from Faidherbia albida (Delile) A. Chev Root-Bark Extracts

Ibrahim Sani, Angela Nnenna Ukwuani-Kwaja, Amina Yusuf Jega, Abdulhamid Zubairu, Fatima Bello

Snake venoms contain several life-threatening toxins, while conventional therapies are available for the snake envenoming. The limitations of these antivenins have driven recent research toward the isolation and characterization of plant-derived antivenin compounds that complement synthetic antivenins

Drug Discovery, 2026, 20(45), e4dd3039

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REPORT

Effect of Ethanolic leaf extract of Jatropha gossypiifolia on the Stomach of Wistar Rats

Unwana E Mishael, Eno-obong I Bassey, Gabriel Edem

The study investigated the effects of the administration of ethanolic leaf extract of Jatropha gossypiifolia, on the stomachs of twenty adult male Wistar rats, which were divided into four groups of five (weighing 80-120g).

Drug Discovery, 2026, 20(45), e5dd3043

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ARTICLE

Development and evaluation of coprocessed Terminalia avicennoides gum resin as drug-release matrix for aceclofenac tablet

Nnabuike Didacus Nnamani, Ibrahim Khaleed Muazu

Modification of biomaterials is continually providing new and improved excipients for drug formulation and delivery. The goal of this research was to evaluate the drugrelease potential of Terminalia avicennoides gum resin matrix

Drug Discovery, 2026, 20(45), e6dd3049

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Molecular docking study for the interaction behavior of human acetylcholinesterase catalytic activity with common organophosphate pesticides

Hala A Abdelgaid, Khairy A Ibrahim

Organophosphate pesticides (OPs) are the most commonly used pesticides and act as key inhibitors of acetylcholinesterase (AChE). However, their mechanism of action in human AChE (hAChE) is not well studied

Drug Discovery, 2026, 20(45), e7dd3053

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Copper sulphate and its implications on lipid profile, serum electrolytes and cerebellar histology

Christopher Chiedozie Mbadugha, Michael Ebe Nandi, Ikechukwu Ezeah, Akpanabasi Alexis Malachy, Ernest Aniefiok Daniel

Copper is essential in tiny amounts, but animal and cell studies show that excess copper sulphate is directly toxic to the body, mainly through oxidative stress, inflammation, and cell death

Drug Discovery, 2026, 20(45), e8dd3057

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Effects of Tetrapleura tetraptera fruit ethyl acetate fraction, apigenin and fluoxetine on the testes of Swiss mice exposed to stress

Eno-Obong I. Bassey, Osayuwame B. Davies, Akpanabasi A. Malachy, Moses B. Ekong, Iniobong G. Essien

Stress significantly influences changes in numerous physiological processes and may contribute to various disorders, including male sub-fertility or infertility.

Drug Discovery, 2026, 20(45), e9dd3059

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Glycaemic and Biochemical Changes in Response to Syzygium Aromaticum Administration in Diabetic Rats

Ilochi Nwabunwanne Ogadinma, Arthur Nwafor Chuemere, Omueti Shalom Crownwell

This study assessed the glycaemic and biochemical changes in response to Syzygium aromaticum administration in diabetic rats. The animals were sampled into 6 groups of 5 rats each

Drug Discovery, 2026, 20(45), e10dd3067

Abstract | PDF