Volume 20, Issue 45, January - June, 2026

Development and evaluation of coprocessed Terminalia avicennoides gum resin as drug-release matrix for aceclofenac tablet

Nnabuike Didacus Nnamani^♦, Ibrahim Khaleed Muazu

Department of Pharmaceutics and Pharmaceutica Technology, Dora Akunyili College of Pharmacy, Igbinedion University, Okada, Edo State, Nigeria.

^♦Corresponding Author
Nnabuike Didacus Nnamani, Department of Pharmaceutics and Pharmaceutica Technology, Dora Akunyili College of Pharmacy, Igbinedion University, Okada, Edo State, Nigeria.

ABSTRACT

Modification of biomaterials is continually providing new and improved excipients for drug formulation and delivery. The goal of this research was to evaluate the drugrelease potential of Terminalia avicennoides gum resin matrix in aceclofenac tablets. Aceclofenac-gum resin interaction studies were carried out using infrared, microscopy, and calorimetric analysis. The gum resin was co-processed with acacia or starch. Batches A- I of aceclofenac granules were formulated with 47.4 % matrices of gum resin, acacia, starch, or their co-processed forms. The granules were subjected to pre-compression properties tests, and thereafter compressed into tablets. The tablets were examined for physicochemical and drug release properties. The gum resin showed compatibility with aceclofenac powder. The granules showed good processing properties. The tablets formulated with co-processed gum resin matrices showed strong mechanical properties with hardness > 6.83 KgF and friability < 0.52 %. Tablets with 1:3 gum resin: acacia co-excipient binder fitted to Fickian diffusion Higuchi release model with coefficient of correlation 0.9929 and release exponent - 0.658. The findings demonstrate that Terminalia avicennoides gum resin co-processed with acacia extended acacelofenac drug release.

Keywords: Pre-compression properties, drug release kinetics, Fickian diffusion, Higuchi release model

Drug Discovery, 2026, 20(45), e6dd3049

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Published: 21 February 2026