ARTICLE
Evaluation of in utero developmental toxicity of metformin hydrochloride in male albino rats
Chukwuemeka Chukwubuikem Okoro, Emeka Chinedu Ifediba, Onyenmechi Johnson Afonne
Metformin is an oral antidiabetic drug of the biguanide family that is used in the management of diabetes and some forms of female factor infertility
Drug Discovery, 2024, 18(41), e1dd1961
Abstract | PDF
Decoding facial paralysis: Investigating potential small molecules for Moebius syndrome therapy
Sheilina Choudhary
Objective: The goal of this study is to conduct a thorough assessment of current knowledge about Moebius syndrome, including clinical symptoms, etiology, and related disorders.
Drug Discovery, 2024, 18(41), e2dd1962
Abstract | PDF
Immuno-modulation and antioxidative roles of olive oil and bee honey following administration of crude oil to Wistar rats
Nwikoleh NL, Ita SO, Abia ER
The immuno-modulation and anti-oxidative roles of olive oil and bee honey following administration of crude oil to Wistar rats was investigated
Drug Discovery, 2024, 18(41), e3dd1963
Abstract | PDF
Antibacterial activity and partial characterization of antibacterial agent from combretum glutinosum leaf extracts against microbes isolated from dental caries
Ibrahim Sani Shabanda, Yusuf Haruna, Aishatu Abubakar Usman
Medicinal plant synthesizes phytochemicals through secondary metabolism; these metabolites can be utilized for several pharmacological approaches, and also serves as precursors for the synthesis of valuable drugs
Drug Discovery, 2024, 18(41), e4dd1967
Abstract | PDF
Titrimetric and thin layer chromatographic fingerprint analysis of captopril solid dosage form – an Angiotensin- Converting Enzyme Inhibitor
Samuel J Bunu, Somtochukwu Kela−Eke, Benjamin U Ebeshi
Captopril is an angiotensin-converting enzyme inhibitor (ACEI), that prevents the conversion of Angiotensin I to Angiotensin II, thereby decreasing blood pressure by lowering peripheral vascular pressure without increasing cardiac output or contractibility
Drug Discovery, 2024, 18(41), e5dd1964
Abstract | PDF
Relationship between cadmium toxicity, kidney function disturbances and urinary bladder inflammation: The role of Uvaria chamae in mitigating these effects
Gabriel Edem, Jessica David, Kingsley Okon, Hope Thompson
The aim of this study was to investigate the ameliorative effects of Uvaria chamae against cadmium-induced toxicity on the urinary bladder and kidney function biomarkers of Wistar rats, considering its recognized local health benefits
Drug Discovery, 2024, 18(41), e6dd1968
Abstract | PDF
Effect of L-dopa or bromocryptine alone or in combination with cannabis on oxidative stress, inflammation and neurodegeneration in experimental Parkinson’s disease
Omar ME Abdel-Salam, Eman R Youness, Enayat A Omara, Amany A Sleem
This study aimed to investigate whether cannabis would modulate the effects of the antiparkinsonian drugs L-dopa or bromocryptine on striatal oxidative stress, neuroinflammation, and neuronal integrity
Drug Discovery, 2024, 18(41), e7dd1970
Abstract | PDF
Molecular simulation of bioactives from Jimsonweed (Datura stramonium) against Plasmodium falciparum - glutathione-Stransferase
Peter Folorunsho Ayodele, Isaac Abiodun Adeniyi, Adekunle Toyin Bamigbade, Olaniyi Stephen Omowaye, Abiodun Joseph Seweje, Maji Emmanuel Adejoh
Introduction: Jimsonweed is a medicinal plant. Malaria is a crucial health problem that is accountable for several deaths yearly across the globe
Drug Discovery, 2024, 18(41), e8dd1972
Abstract | PDF
Free Radicals scavenging potency of ethanolic fruit extract of Selim pepper (Xylopia aethiopica)
Peter Folorunsho Ayodele, Adio Jamiu Akamo, Lukman Bolaji Bello, Samuel Tobi Farohunbi, Adekemi Titilayo Adesulu-Dahunsi, Oluseyi Adeboye Akinloye
Introduction: Free radicals (FRs) are unstable molecular species with unpaired electrons, capable of causing damage to cells and the human body, leading to illness and aging
Drug Discovery, 2024, 18(41), e9dd1974
Abstract | PDF
Phytochemical analysis, Thin Layer Chromatography and Gas Chromatography Mass Spectroscopy profile of colocasia esculenta and manihot esculanta extracts and their potential for drug discovery
Ismail Rabiu, Muhammad Yusha’u, Jaafaru Isah Abdullahi, Abdulazeez Muhammed
Many infectious diseases have been known to be treated with herbal remedies throughout the history of mankind.
Drug Discovery, 2024, 18(41), e10dd1975
Abstract | PDF
Formulation and in vitro evaluation of gastroretentive accordion poly pill containing captopril and glibenclamide
Muhammad Abid Mustafa, Maria Munawar, Laiba Nadeem, Maria Faisal Khan, Namra Rasheed, Ifra Asif, Usman Imtiaz, Mehak Ilyas, Iqra Akhtar, Mahnoor Malik, Aqsa Shafiq, Afshan Abdul Shakoor
Background: The study aims to create a new oral dosage form for patients with hypertension and diabetes, focusing on a sustained gastroretentive formulation
Drug Discovery, 2024, 18(41), e11dd1981
Abstract | PDF
Phytochemical analysis and antimicrobial investigation on leaf and fruit extracts of L. aegyptiaca Mill
Arulraj S
The study aimed to explore the phytochemical constituents and antimicrobial properties of L. aegyptiaca Mill. [Syn.: Luffa cylindrica M.Roem.] (Cucurbitaceae) leaf and fruit extracts
Drug Discovery, 2024, 18(41), e12dd1979
Abstract | PDF
Prescribing pattern of antihypertensive agents in patients with Type 2 Diabetes patients visiting governmental hospital in Yemen capital city, Sana’a
Khaled Mohammed Alakhali, Ali Salman Alshami, Abdullah Ahmed Al-dahbali, Sakran Faiz Khaled Mohammed
Background: The prevalence of hypertension has been observed to be high among individuals diagnosed with type 2 diabetes mellitus. Furthermore, the coexistence of both illnesses has been linked to an elevated susceptibility to cardiovascular problems
