Volume 18, Issue 41, January - June, 2024

Phytochemical analysis, Thin Layer Chromatography and Gas Chromatography Mass Spectroscopy profile of colocasia esculenta and manihot esculanta extracts and their potential for drug discovery

Ismail Rabiu^1♦, Muhammad Yusha’u², Jaafaru Isah Abdullahi³, Abdulazeez Muhammed⁴

¹Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Republic of China Taiwan
²Department of Microbiology, Faculty of Life Sciences, College of Natural and Pharmaceutical Sciences, Bayero University, PMB 3011, Kano, Nigeria
³Department of Microbiology, Kaduna State University, PMB 2339, Kaduna State, Nigeria
⁴Department of Microbiology, School of Science and Information Technology, Skyline University Nigeria. No. 2, Zaria Road, Kano, Nigeria

^♦Corresponding author
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Republic of China Taiwan

ABSTRACT

Many infectious diseases have been known to be treated with herbal remedies throughout the history of mankind. Over the years, these herbal remedies obtained from medicinal plants have proven to be a remarkable source of newer and more potent therapeutic agents and have therefore taken the central stage in most research centers in the world. The aim of this research is to analyzed Colocassia esculenta and Manihot escalanta plants for the presence of the bioactive compounds and as well assess their potential for drug discovery. Fresh Leaves of the two plants were collected from Kaduna Nigeria and Phytochemical analysis, Thin Layer Chromatography (TLC), and Gas Chromatography-Mass Spectroscopy (GCMS) were carried out on the aqueous and methanolic extracts of the two leaves. The presence of tannins, flavonoids, alkaloids, phenols, and saponins was observed in all the extracts. TLC gave four and five separate bands for the aqueous and Methanol extracts respectively with Rf values ranging from 0.12 to 0.90. Among the two plants, M. esculenta extracts were identified via GCMS as having the highest number of different compounds (35) with C. esculenta having 26. The results obtained in this study revealed the extracts as having different bioactive agents capable of having inhibitory activity thereby showcasing the possibility of better chemotherapeutic outcomes in the treatment of bacterial, fungal, and viral infections.

Keywords: Colocasia esculenta, Manihot esculanta, Medicinal plants, Gas Chromatography-Mass Spectroscopy, Thin Layer Chromatography

Drug Discovery, 2024, 18(41), e10dd1975

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DOI: https://doi.org/10.54905/disssi.v18i41.e10dd1975

Published: 30 March 2024