Volume 29, Issue 165, November 2025

Endometrial cancer – Is standardized treatment sufficient? Recurrence of endometrial cancer in the vulva – case report

Julia Niedziółka^1♦, Wiktoria Nicpoń¹, Karolina Frąszczak², Rafał Tarkowski²

¹I Chair and Department of Oncological Gynaecology and Gynaecology, Student Scientific Association, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland.
²I Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland.

^♦Corresponding author
Julia Niedziółka I Chair and Department of Oncological Gynaecology and Gynaecology, Student Scientific Association, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland

ABSTRACT

A 63-year-old woman, previously treated for endometrial cancer using chemoradiotherapy, came in for additional diagnosis. Imaging studies showed uterine tumors that had extended to the parametrium. The patient had a radical hysterectomy along with bilateral salpingo-oophorectomy. The histopathological examination verified G2 endometrioid adenocarcinoma (FIGO stage II) and a borderline ovarian tumor. Because of a p53 mutation, the patient received adjuvant chemotherapy and brachytherapy. Follow-up MRI revealed suspicious lesions in the vaginal and vulvar areas, including a mass in the left labium majus. The doctor initiated hormonal therapy. Given the tumor size, surgical excision of the vulvar lesion and vaginal nodules was performed, with histopathology confirming recurrence of endometrioid carcinoma. Due to further disease progression, the medical team introduced immunotherapy. This case is an example of a rare location of endometrial cancer recurrence on the vulva and in the vagina. It highlights the need for an individualized approach to each patient, analysis of possible treatment strategies, and selection of the appropriate therapy, particularly in patients with high-risk molecular profiles.

Keywords: endometrial cancer, vulvar metastasis, treatment

Medical Science, 2025, 29, e218ms3734

PDF

DOI: https://doi.org/10.54905/disssi.v29i165.e218ms3734

Published: 29 November 2025