Volume 29, Issue 162, August 2025

A Systematic Review of the Latest Treatments and Risk Factors in Pregnant Women with Systemic Lupus Erythematosus

Natalia Sioch^♦, Julia Urbańska, Julia Sztubińska, Marta Urszula Marciniak, Marta Tortyna, Julia Krotofil, Paula Szarek, Olga Samsel, Kamil Nieczaj, Maciej Trzciński, Danuta Borowska

Faculty of Medicine, Medical University of Gdańsk, Poland

^♦Corresponding author
Natalia Sioch, Faculty of Medicine, Medical University of Gdańsk, Poland

ABSTRACT

This paper reviews the important medical problem of women with systemic lupus erythematosus during pregnancy. As an autoimmune disease, lupus can significantly impact the health of both mother and baby, making these pregnancies high-risk and requiring close monitoring as well as a team approach to care. This article will also present the most frequent problems encountered during pregnancy in these women, such as flares of the disease, obstetric complications, and fetal risk. Special attention is given to the use of medications. The article discusses drugs which can be used safely and are effective during pregnancy, those that are not harmful to the fetus and can keep the progress of the disease in check through the mother. Moreover, it will review the current state of treatment, and particularly therapeutic approaches developed over the last 10 years, for which scientific evidence and clinical experience are available. The purpose of this review is to emphasize the special difficulties encountered when treating pregnant women with SLE and to present clinical strategies that can improve the likelihood of a healthy pregnancy and delivery for both the mother and infant.

Keywords: Systemic lupus erythematosus (SLE), systematic literature review, pregnant women, pharmacological treatment methods

Medical Science, 2025, 29, e147ms3633

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DOI: https://doi.org/10.54905/disssi.v29i162.e147ms3633

Published: 30 August 2025