Volume 29, Issue 156, February 2025

Inositol – multidimensional support for metabolic and mental health

Paulina Fijałek^1♦, Jan Karczmarz¹, Aleksandra Paprocka², Marika Gutowska³, Agnieszka Kosińska⁴, Urszula Świrk⁵, Wiktoria Belcarz⁶, Karolina Kalinowska⁷, Michał Orzechowski⁸, Joanna Orzechowska⁸

¹Southern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, Poland
²Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wroclaw, Poland
³Józef Struś Multi-Specialist Municipal Hospital, Szwajcarska 3, 61-285, Poznań, Poland
⁴District Hospital in Chrzanow, Topolowa 16, 32-500 Chrzanow, Poland
⁵Independent Public Health Care Facilities in Przasnysz, Dr. Wojciech Oczko Hospital, Sadowa 9, 06-300 Przasnysz, Poland
⁶Murcki Hospital Sp. z o.o., Sokołowskiego 2, 40-749 Katowice, Poland
⁷Health Care Team of the District Hospital in Sochaczew, Batalionów Chłopskich 3/7, 96-500 Sochaczew, Poland
⁸Jędrzej Śniadecki Specialist Hospital in Nowy Sącz, Młyńska 10, 33-300 Nowy Sącz, Poland

^♦Corresponding Author
Southern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, Poland

ABSTRACT

Inositol, a naturally occurring compound from the glucose family, is crucial in maintaining metabolic and mental health. The two most physiologically active isomers, myo-inositol (MI) and D-chiro-inositol (DCI), are involved in important cellular processes such as insulin signaling, lipid metabolism, and neurotransmitter modulation. This article explores the various aspects of inositol, including its physiological processes, nutritional sources, and medicinal uses. Inositol is showing promise in treating conditions including insulin resistance, type 2 diabetes, polycystic ovary syndrome (PCOS), and mood disorders such as depression, panic disorder, and obsessive-compulsive disorder (OCD). With a favorable safety profile, this natural origin makes it an attractive alternative or adjunctive therapy for metabolic and mental health conditions. Further work is necessary to optimize supplementation strategies, address uncertainties regarding mechanisms of action, and assess long-term benefits in other populations.

Keywords: Inositol, Polycystic ovary syndrome, Mental health, Hormonal balance, Neurotransmitter modulation

Medical Science, 2025, 29, e23ms3530

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DOI: https://doi.org/10.54905/disssi.v29i156.e23ms3530

Published: 01 February 2025