Volume 28, Issue 154, December 2024

Autoimmune syndrome induced by breast implants

Aisha Hassan^1♦, Sara Hassan², Szymon Bienia², Wafa Al- Batool³, Aleksandra Kossakowska¹, Jakub Leicht¹, Paweł Godlewski¹, Klaudia Konieczna⁴, Izabela Zarecka³, Anna Gwóźdź-Broczkowska¹, Bartosz Górecki¹

¹Cardinal Stefan Wyszyński University in Warsaw, Wóycickiego 1/3, 01-938 Warsaw, Poland
²Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland
³Wroclaw Medical University, wyb. Ludwika Pasteura 1, 50-367 Wrocław, Poland
⁴Medical University of Silesia, Dr. Henryka Jordana 19, 41-808 Zabrze, Poland

^♦Corresponding Author
Cardinal Stefan Wyszyński University in Warsaw, Wóycickiego 1/3, 01-938 Warsaw, Poland

ABSTRACT

Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) is a catchall name for immunologically-based disorders that develop in genetically predisposed persons after exposure to adjuvants such as silicone breast implants. This article summarizes the existing literature on ASIA, focusing on the link between breast implants and the development of autoimmune diseases. Breast implants have grown in popularity in cosmetic surgery since the 1960s, but their use offers significant health risks, such as inflammatory responses and autoimmune problems. The study clarifies research findings on the pathophysiology of ASIA, focusing on the impact of silicone leaks on the immune system and infiltration into surrounding tissues. It intensively examines the processes that cause foreign body reactions and the potential function of adjuvants in triggering the immune response. Review focuses on silicone mobility and the production of bacterial biofilms, both related to prolonged inflammatory reactions. The findings suggest that more research into implant operation techniques is needed to improve understanding of the risks and provide safer choices for patients. The authors underline the importance of raising patient and professional knowledge about the possible hazards of breast implants, as well as encouraging greater research into silicone-free breast reconstruction techniques.

Keywords: Autoimmune/inflammatory syndrome induced by adjuvants, silicone breast implants, breast implant illness

Medical Science, 2024, 28, e150ms3476

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DOI: https://doi.org/10.54905/disssi.v28i154.e150ms3476

Published: 18 December 2024