Volume 28, Issue 153, November 2024

A rare case report of a diagnostic dilemma: Cervical leiomyosarcoma versus Extraintestinal Gastrointestinal Stromal Tumor

Bhaswati Bhattacharyya^♦, Veerendra Kumar KV, Nataraj Y Sannappanavar, Varun Kulkarni

Department of Surgical Oncology, Sapthagiri NPS University, Bangalore, Karnataka, India

^♦Corresponding Author
Department of Surgical Oncology, Sapthagiri NPS University, Bangalore, Karnataka, India

ABSTRACT

Aim: The aim of this study is to report a rare case that posed a diagnostic dilemma between cervical leiomyosarcoma (LMS) & extraintestinal gastrointestinal sarcoma (GIST). Methodology: A 47 years old postmenopausal female with a history of whitish foul-smelling vaginal discharge for three months presented to our department. Per vaginal & per speculum examination showed a massive exophytic cervical growth. On cervical biopsy, it was suggestive of leiomyosarcoma. Positron emission tomography-computed tomography (PETCT) scan did not reveal any visceral metastasis. She underwent nerve sparing modified radical hysterectomy. The retrieved specimen was sent for final histopathological evaluation (HPE) and immunohistochemical staining (IHC). This was followed by mutational analysis of the specimen. Conclusions: This study has shown a CD117 & CD34 immunoreactive sarcoma masquerading as an extraintestinal GIST. CD117 is not specific for GIST. The use of biomarkers and molecular testing is indispensable for a thorough evaluation. Surgery is the primary modality of treatment. Following surgery, the patient has undergone adjuvant chemotherapy. There was no evidence of tumor recurrence after 12 months of follow up.

Keywords: Cervix, sarcoma, immunohistochemistry, cd117, mutational analysis

Medical Science, 2024, 28, e141ms3459

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DOI: https://doi.org/10.54905/disssi.v28i153.e141ms3459

Published: 27 November 2024