Volume 28, Issue 151, Septemper 2024

Design, fabrication, and in-vitro characterization of pHresponsive sustained-release super porous hydrogel containing metformin HCl

Muhammad Abid Mustafa¹, Gohar Jaan², Amna Nadeem², Javeria Khan², Javaria Nadeem², Fatima Javed², Maryam Mazhar², Amna Sajjad², Kiran Fatima², Anam Khaliq², Aman Saif², Zarqa Saqib², Muhammad Zahid Iqbal^3♦

¹Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan
²Research Student, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan.
³Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan

^♦Corresponding Author
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan

ABSTRACT

Objective: The aim of this study is to develop a superporous hydrogel containing metformin HCl that improves patient compliance by providing a convenient dosage regime, reducing the dosing frequency, and decreasing the side effects by providing sustained release. The super porous hydrogel offers a pH-sensitive response. Methodology: The study includes the free radical polymerization along with gas foaming agent with NaHCO3, acrylic acid, acrylamide monomers, and natural polymers like tragacanth, locust bean gum, and kappa carrageenan. Results: The DSC and TGA analysis confirmed thermal stability, and the influence of a forming agent to develop a superporous structure was confirmed through an SEM analysis. XRD shows the not distinctive peak to confirm the incorporation of the API in the hydrogel. The in vitro drug release was over 13 hours, offering sustained drug release and fickain diffusion. Conclusion: The superporous hydrogel is a highly pH-sensitive and porous structure. It offers a sustained drug release in an alkaline medium, suggests an effective therapeutic outcome, and improves a patient's compliance.

Keywords: pH sensitive, Metformin HCL, Sustained Release, Green Synthesis

Medical Science, 2024, 28, e122ms3426

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DOI: https://doi.org/10.54905/disssi.v28i151.e122ms3426

Published: 09 Septemper 2024