Introduction: Glanzmann's thrombasthenia (GT) is a rare disease inherited in an
autosomal recessive manner. Qualitative or quantitative defect of the adhesive
protein that binds to the platelet receptor in the coagulation process causes this
disease. In most cases, symptoms appear in early childhood. The aim: This study
aims to present the diagnostic and therapeutic problem in a patient with GT. Case
report: A 70-year-old patient hospitalized due to symptomatic anemia. Initially
the patient was diagnosed with hemophilia, later the diagnosis was changed to
Glanzmann thrombasthenia. The patient's last hospitalization was in 2024, during
which gastroscopy and colonoscopy was performed. No pathological changes
were detected. Results: Glanzmann thrombasthenia is characterized by an
average platelet count and morphology, standard prothrombin time, and
standard partial thromboplastin time, accompanied by prolonged bleeding time.
The diagnosis is usually based on flow cytometry, which shows the absence of
GPIIb or GPIIIa molecules on the platelet surface. Conclusions: Glanzmann
thrombasthenia (GT) is a rare genetic disease that causes symptoms of bleeding
diathesis. Quick diagnosis and appropriate treatment are crucial for managing
this condition. Treatment options include transfusions of platelet concentrate,
antifibrinolytic drugs, recombinant factor VIIa, and hematopoietic cell
transplantation.
Keywords: Glanzmann’s thrombasthenia, Bleeding, diagnosis, treatment,
inherited thrombocytopathy