Volume 28, Issue 147, May 2024

Fabrication and in-vitro characterization of mucoadhesive tablet using a natural biocompatible polymer containing metformin HCl

Muhammad Abid Mustafa^1♦, Asad Majeed Khan¹, Muhammad Hassan², Hamza Saeed², Fatima Sabir², Iqra Mushtaq², Namra Rasheed², Iqra Rasheed², Muhammad Arsh², Minahil Arif², Afshan Abdul Shakoor²

¹Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan
²Research Student, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan

^♦Corresponding author
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan

ABSTRACT

Background: Drug delivery mucoadhesion has been a subject of study for decades, initially focusing on understanding processes and investigating polymers. Mucoadhesive tablets are oral dosage forms that adhere to mucosal surfaces, promoting prolonged contact and localized drug delivery. Aim and Objective: A mucoadhesive tablet formulation of metformin could enhance drug delivery and improve therapeutic outcomes for patients with type 2 diabetes. Material and Method: The wet granulation process is used to develop mucoadhesive tablets by developing granules with the ideal characteristics for compression and tablet production. The process involves the use of natural mucoadhesive polymers like pectin and xanthan gum, along with the active component of metformin. Various testing techniques, such as weight variation, friability, hardness, DSC, TGA, XRD, in vitro dissolution, and release kinetics, are used to evaluate mucoadhesive tablets. Result and Discussion: Most formulations exhibited optimal test results within official limits in terms of friability, weight variation, and hardness. Thermal analysis indicated a transition within the temperature range, showed an exothermic peak in DSC analysis, and demonstrated temperature stability in thermogravimetric analysis. In vitro dissolution studies revealed exceptional drug release, reaching approximately 101% over 12 hours. The release kinetics modeling, performed through regression analysis, indicated sustained release. The n-exponent of the Korsmeyer and Peppas models suggested Fickian drug release. Conclusion: The successfully synthesized mucoadhesive tablets, formulated with natural and biocompatible mucoadhesive polymers, exhibit optimal drug release properties. They are utilized for prolonged drug release for up to 12 hours, aiding in diabetic management through metformin.

Keywords: Natural polymers, mucoadhesion, Metformin, diabetes type-II, sustained release

Medical Science, 2024, 28, e38ms3335

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DOI: https://doi.org/10.54905/disssi.v28i147.e38ms3335

Published: 14 May 2024