Volume 28, Issue 145, March 2024

Design and fabrication of metoclopramide fast dissolving films by using combined natural and synthetic polymers, and in vitro evaluation

Muhammad Abid Mustafa^♦

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan

^♦Corresponding author
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological & Applied Sciences, Lahore, Pakistan

ABSTRACT

Objective: Formulation aims to develop a film that dissolves quickly for advanced solid dosage forms in order to increase the drug's bioavailability and enhance its action. Natural gum and artificial polymers were combined to develop films with the desired properties. Method: Metoclopramide FDF was developed in nine different formulations (F1–F9) using the solvent casting process. The effect of varying formulation parameters on the physical and mechanical characteristics of metoclopramide films was investigated in vitro using phosphate buffer at 6.8 pH. Several techniques were used to evaluate the films' weight, thickness, tensile strength, folding durability, and oral dissolving time in order to determine the best possible formulation. Results: The findings showed that the materials were employed consistently throughout the whole film in terms of drug content. While all the formulations had acceptable testing features, formulation F7 was deemed the most promising due to its 99.12% in-vitro drug release and other characteristics. All the formulations are shown to obey first-order kinetics and fickian release. The formulation showed enhanced drug release rates over a 9- minute period, indicating its adaptability. It contained the ideal polymer concentrations of Cyamopsis tetragonoloba gum, HPMC, and PEG. Conclusion: The study suggests that metoclopramide fast-dissolving oral films are the most effective antiemetic option for quick onset of action and enhanced bioavailability.

Keywords: Fast dissolving films, oral mucosa, metoclopramide, anti-emetic, Cyamopsis tetragonoloba gum, improved bioavailability, Solvent casting, Filmforming polymers

Medical Science, 2024, 28, e19ms3303

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DOI: https://doi.org/10.54905/disssi.v28i145.e19ms3303

Published: 23 March 2024