Volume 28, Issue 143, January 2024

Efficacy of Airway Pressure Release Ventilation in treating acute respiratory distress syndrome

Mohammed Sagheer Albarqi¹, Saad Alsaad¹, Mania Salem Al-baqawi¹, Kamal Alsofyani¹, Fahad Bader AlGhounaim², Mohammed Sultan Alshehri¹, Rakan Abdullah Alshareef¹, Mortada Hassan Aljassas¹, Faisal Naif Alshammari¹, Ahmed Alsiwar¹

¹Respiratory Therapist, Respiratory Therapy Department, Imam Abdulrahman Alfaisal Hospital, NGHA, Dammam, Saudi Arabia
²Respiratory Therapist, King Abdulaziz Hospital, Home Health Care Department, NGHA, AlAhsa, Saudi Arabia

ABSTRACT

Background: Acute respiratory distress syndrome (ARDS) is a serious condition which necessitates admission to an intensive care unit, is linked to a high rate of hospital death. Refractory hypoxemia is the most significant pathophysiological characteristic of ARDS. Airway pressure release ventilation (APRV) characterized as a constant positive airway pressure with intermittent release phase. It also has a good effect in patient with acute respiratory distress syndrome (ARDS) therapy paradigm. This study set out to assess the effectiveness of APRD in raising oxygenation levels and reducing death rates in severely ill ARDS patient. Method: The study was carried out in compliance with PRISMA criteria. From 2000 to 2022, we looked for researches in Embase, PubMed, the Cochrane Library and Web of Science. Every study that addressed the impact of APRV on adults suffering from ARDS was included. The oxygenation status was our main outcome. Mortality and the length of stay (LOS) in the critical care unit were the secondary outcomes. Results: Six studies were included in this systematic review. Tidal volume was set in 4 to 6 mL/kg in four investigations that evaluated APRV to traditional modes that employ low tidal volume technique. In the other two investigations, tidal volume larger than 6 mL/kg was employed to test APRV to synchronized intermittent mandatory breathing. All trials provided the mortality result; and five studies reported intensive care unit LOS. Conclusion: This study concludes that APRV use have shortened the LOS in the critical care unit and boosted oxygenation on day three.

Keywords: Mechanical ventilation, acute respiratory distress syndrome, airway pressure release ventilation

Medical Science, 2024, 28, e2ms3286

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DOI: https://doi.org/10.54905/disssi.v28i143.e2ms3286

Published: 22 January 2024