Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting
the central nervous system. Objectives: This study aimed to investigate the
effects of Group Therapy based on Quality-of-Life Improvement (GTQOLI)
on the meaning of life, self-compassion, emotional self-regulation, and quality
of life (QOL) in patients with MS. Method: The current study was a pre-testpost-
test randomized clinical trial with a control group and a six-month
follow-up. The statistical population of the research included all the MS
patients who sought treatment at the Specialized MS Clinic of Sina Hospital
Tehran, Iran. With the convenience sampling method, 42 people were
selected as a sample and randomly assigned to two experimental and control
groups. The experimental group received GTQOLI for eight sessions. To
collect data, the Meaning of Life Questionnaire, Affective Style Questionnaire,
Multiple Sclerosis Quality of Life (MSQOL-54), and Self-Compassion Scale
were used. Multivariate analysis of variance test was used to analyze the
data. Result: The results showed a significant difference between the
experimental and control groups in terms of the search for meaning, selfcompassion,
and overall QOL in individuals with MS (P<0.05). The
interaction effect of time and group for the total score of GTQOLI was
statistically significant (F=3.426, P<0.05). Conclusion: In GTQOLI, clients are
taught essential skills for improved life management and the pursuit of life
meaning. This approach enables them to regulate negative thoughts and
build personal goals around valued areas of life. More clinical trials are
needed.
Keywords: Meaning of Life; Self-Compassion; Emotional Self-Regulation;
Quality of Life
