Volume 27, Issue 133, March 2023

Comparing mortality outcomes of early versus late intubation in COVID-19 patients admitted in the ICU: A systematic review and meta-analysis

Abdullah I Aedh^1,2

¹Associate Professor of Internal Medicine, Najran University, KSA
²Medicine and Critical Care Consultant, Najran University Hospital, Saudi Arabia
ORCID: 0000-0001-9831-4249

ABSTRACT

The goal of this systematic review and meta-analysis was to assess whether there is a difference in mortality rates between COVID-19 patients in the ICU who receive early intubation versus those who receive it later. The study also considered potential factors that could affect the results, such as patient characteristics and the length of time that mechanical ventilation was needed. A total of 18 studies were included in the final analysis, comprising a total of 11,228 patients. The meta-analysis did not find a statistically significant difference between the mortality in early versus late intubation, with a risk ratio of 0.97 (95% CI: 0.87-1.07). Subgroup analysis revealed that this result was consistent across various subgroups, including patient age and severity of illness. However, the included studies had moderate to high risk of bias and the possibility of publication bias cannot be ruled out. Further high-quality studies are needed to confirm these findings.

Keywords: Intubation, Mortality, COVID-19

Medical Science, 2023, 27, e156ms2918

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DOI: https://doi.org/10.54905/disssi/v27i133/e156ms2918

Published: 20 March 2023