Volume 27, Issue 133, March 2023

Beneficial role of olive extract on cyclophosphamide-induced skin cellular injury

Salman Bin Dayel¹, Ali Hassan A Ali^2,3♦, Mansour M Alajmi⁴, Turki Saad Alsubaie⁵, Nasser Hassan Alswedan⁵, Musab Alrezehi⁵, Nawaf Saad Alarfaj⁵, Maan Omar Alzuhairi⁵, Emad M Al-Otaibi⁵, Abdullah N Al-Khanfoor⁵, Roaa Salem Alharbi⁶

¹Department of Dermatology, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA
²Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA
³Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
⁴Family & Community Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia
⁵College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, KSA
⁶College of Medicine, Northern Border University, Arar, KSA

^♦Corresponding author
Anatomy Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, KSA and Anatomy Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

ABSTRACT

For centuries, countries in the Mediterranean and all of Europe have employed olive leaves in traditional medicine. This substance has antioxidative stress and anti-inflammatory properties. In this work, the potential protective effects of olive extract were investigated in relation to the histochemical and histological alterations in the skin of rats following exposure to cyclophosphamide. Thirty-six mature male albino rats served as the subjects for the current study. There were three equal groups formed from them. The control group received no medical treatment. Animals in the cyclophosphamide group were given 100 mg kg BW one dose of cyclophosphamide intraperitoneally. Rats in the third group received daily dosages of 15 mg/kg body weight of olive extract for one week prior to and one week following the injection of cyclophosphamide. Various stains were used to examine the histopathological as well as histo-chemical alterations in skin tissue. Cyclophosphamide-exposed rats' skin underwent a number of histological and histochemical alterations. Administering Olive Extract helped to improve these changes. The current study demonstrated olive extract's curative and preventive effects on albino rats' skin against cyclophosphamide-induced skin damage.

Keywords: Olive Extract, cyclophosphamide, Skin injury

Medical Science, 2023, 27, e131ms2934

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DOI: https://doi.org/10.54905/disssi/v27i133/e131ms2934

Published: 05 March 2023