Volume 27, Issue 132, February 2023

Dubin-Johnson syndrome: A rare case report

Apoorv Jain^1♦, Amar Taksande²

¹Post Graduate Resident, Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India
²Professor and Head, Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India

^♦Corresponding author
Post Graduate Resident, Department of Pediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India

ABSTRACT

Dubin-Johnson syndrome is an inherited metabolic disorder in which the primary defect is in the MRP2 protein, which leads to an overflow of conjugated bilirubin in the blood leading to hyperbilirubinemia. It is a benign disorder that develops from a genetic defect in bilirubin pigment secretion that causes persistent jaundice and conjugated hyperbilirubinemia. Multiple cases of hyperbilirubinemia disorders similar to Dubin-Johnson syndrome were reported, but each varies in the levels of conjugated bilirubin and its response to the treatment. This syndrome's clinical cases are often misdiagnosed and mistreated as mostly the affected individuals are asymptomatic. In this clinical case report, a 23-year-old female patient was admitted to the hospital with chief complaints of recurrent jaundice and abdominal pain. Additional examination and testing revealed that she had been jaundiced from birth and had a family history of the same. She was managed conservatively and follow-up revealed a good prognosis. This article describes a case of Dubin-Johnson syndrome that is incredibly unusual. However, the patients have an average life expectancy and don't require any therapy.

Keywords: Dubin Johnson Syndrome, Hyperbilirubinemia, MRP2 protein, Conjugated bilirubin

Medical Science, 2023, 27, e117ms2836

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DOI: https://doi.org/10.54905/disssi/v27i132/e117ms2836

Published: 27 February 2023