Volume 26, Issue 130, December 2022

COVID 19 severity, ICU need and outcome in asthmatic patients

Qais zaid Alhamdan¹, Sultan Hudaib Aljaid², Seham Yahya Alzahrani², Abdulrahim Yousef Alomran³, Abeer Ishq Alosaimi⁴, Deemah Adnan Alafaliq⁵, Fatima Ali Alghanem⁴, Heba Essam Fahmy⁴, Khulood Abdullah Bayazeed³, Kumail Abdulmonem M Albahrani⁴, Malak Husain Al Ramadhan³, Mohammed Ali Radhi Alburi⁶, Zahra Abdullah Ali Al Musa³, Zainab Ahmed Adnan Alawami³, Zainab Ahmed Ali Albetiyan³

¹Emergency Consultant, Emergency Department, General Hospital King Saud Medical City, Riyadh KSA
²Emergency resident, Emergency department, General Hospital, KSMC, KSA
³Medical intern, Medical University of Warsaw, Poland
⁴Medical intern, Vision College of Medicine, Vision College, Riyadh, Saudi Arabia
⁵General Physician, King Faisal University, Al-ahsa, Saudi Arabia
⁶General Physician, Vision College of Medicine, Vision College, Riyadh, Saudi Arabia

ABSTRACT

There is insufficient data to definitively establish the link between coronavirus disease 2019 and asthma, despite reports that individuals with comorbidities are more likely to experience unfavorable clinical outcomes. On account of this, the objective of this study is to carefully analyze the clinical traits of asthmatic COVID-19 patients. 18 COVID-19 patients with asthma and 101 COVID-19 patients without asthma were statistically matched in this single-center, retrospective and observational cohort study using propensity scores based on age, sex and comorbidities. In the meantime, data on demographic variables, clinical and laboratory tests and results were gathered and compared between the two groups to identify any differences. According to statistics, patients on the COVID-19 who had asthma had a higher proportion of ICU admissions than those who did not. Additionally, asthma patients showed greater levels of inflammatory responses such as interleukin 6, interleukin 8, procalcitonin, leukocytes, neutrophils, and CD4+ T cells. Additionally, COVID-19 patients with asthma had more significant increases in organ damage markers such D-dimer, lactate dehydrogenase and high-sensitivity cardiac troponin I. In COVID-19 asthma patients, exacerbated inflammatory responses and numerous organ damages were induced, highlighting the need for excessive intense surveillance and supportive care.

Keywords: COVID 19, asthma, clinical traits

Medical Science, 2022, 26, ms522e2632

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DOI: https://doi.org/10.54905/disssi/v26i130/ms522e2632

Published: 11 December 2022