Volume 26, Issue 126, August 2022

Coinfection of HPV18 with some high-risk less frequent HPV subtypes

Musa Abdalla Ali^1♦, Saleh Hussein Bensumaidea², Hussain Gadelkarim Ahmed¹

¹Faculty of Medical Laboratory Science, University of Khartoum, Sudan
²Department of Pathology, College of Medicine, Hadhramout University of Science and Technology, Yemen

^♦Corresponding author
Faculty of Medical Laboratory Science, University of Khartoum, Sudan

ABSTRACT

Background: High-Risk Human Papillomavirus (HR-HPV) is a major health concern worldwide. Thus, this study aimed to assess the coinfection of HPV18 with some high risk less frequent HPV genotypes including HPV subtypes 31, 33, 35, 39, 45, 52, 56, 58, 59 and 66. Methodology: This is a retrospective study of 200 cervical samples retrieved from Yemeni histopathological laboratories exist in Hadhramout, Yemen. All samples were formalin-fixed paraffin wax-processed tissues. All specimens had a previous diagnosis of cervical cancer by conventional histopathology. Results: The most common pathological condition was squamous cell carcinoma (SCC), followed by adenocarcinoma, CIN3, and CIN1, accounting for 53.3%, 12.7%, 10.7%, and 10%, respectively. Coinfection with HPV 18 was detected in 12.5% with 3% with HPV 31, HPV35, and 3% with HPV58. Conclusion: Infection with HPV is widespread and the causes of increased cases of cervical cancer. The most common genotypes of HPV that coinfect with HPV subtype 18 are HPV31, HPV35, and HPV58.

Keywords: Human Papillomavirus, Coinfection, Cervical cancer, Yemen, HRHPV

Medical Science, 2022, 26, ms342e2370

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DOI: https://doi.org/10.54905/disssi/v26i126/ms342e2370

Published: 18 August 2022