Volume 26, Issue 126, August 2022

Early detection of acute renal failure by serum cystatin C in type 2 diabetes patients in Parul Sevashram hospital at Waghodia, Vadodara

Disha A Chandera¹, Dhruvi M Patel^2♦, Ketan Mangukiya³

¹M.Sc. Medical Laboratory Technology student, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara, Gujarat, India
²Assistant Professor, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara, Gujarat, India
³MD Pathologist & Associate Professor of Department of Biochemistry Parul Institute of Medical Science and Research, Parul University, Vadodara, Gujarat, India

^♦Corresponding author
Assistant Professor, Department of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara, Gujarat, India

ABSTRACT

Aim: The early stages of acute renal failure are poorly diagnosed by current routine tests. We studied the correlation between cystatin C and creatinine in Type 2 diabetes patients. Introduction: The present study was carried out on 52 subjects with type 2 diabetes mellitus. All subjects were tested for various parameters like, serum cystatin C, serum creatinine, HbA1C, FBS, and, PP2BS. Analysis of Glomerular filtration rate was done using national kidney foundation formula. To analyze data Excel is used for SD value and Social Science Statistics for P value. Method: ScyC levels increased significantly in type 2 diabetes patients (p<0.001) as compare to SCre level. A positive correlation was present between ScyC and SCr (r=0.309, p<0.005). Both SCysC (r=-0.184) and SCr (r=-0.309) had adverse correlation with eGFR (p<0.005). Result: Serum cystatin C can be recognised as an immediate marker to detect nephropathy and renal dysfunction in diabetic patients than serum creatinine. Furthermore, this study needs to be conducted with a largest population to confirm this.

Keywords: Acute Renal Failure, Creatinine, Cystatin C, Glomerular Filtration Rate, Type 2 Diabetes

Medical Science, 2022, 26, ms335e2368

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DOI: https://doi.org/10.54905/disssi/v26i126/ms335e2368

Published: 11 August 2022