Volume 26, Issue 125, July 2022

Midtrimester pregnancy loss in IVF conception due to parvovirus -A twisted tale of gravid

Tanvi Chaurasia¹, Deepti Shrivastava^2♦, Kamlesh Chaudhary², Rahul Agola³, Geeta Chaurasia⁴

¹Post Graduate Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India
²Professor, Department of Obstetrics and Gynaecology, Jawaharlal Nehru medical college, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India
³Post Graduate Resident, Department of Orthopaedics, Jawaharlal Nehru medical college, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India
⁴Senior consultant, Department of Obstetrics and Gynaecology, District hospital Chhatarpur (Madhya Pradesh), India

^♦Corresponding author
Professor, Department of Obstetrics and Gynaecology, Jawaharlal Nehru medical college, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, India

ABSTRACT

Mid trimester pregnancy loss due to parvovirus infection in patients with IVF conception is an infrequent finding encountered in pregnancy and is associated with high output cardiac failure, anemia, and hydrops fetalis. Effects may range from an uncomplicated pregnancy to severe hydrops fetalis or intrauterine fetal death. Parvovirus B19 causes prolonged epidemics of erythema infectious, particularly in primary school-aged children. Infection produces clinically significant anemia in those who have a high red cell turnover rate, such as the fetus. Infection affects around 40% of women of reproductive age, with annual seroconversion rates ranging from 1.5 percent during endemic periods to 10-15 percent during epidemics. Around 50% of susceptible women infected at home are infected, and 20-30% gets infected after professional exposure, such as in a primary school. Maternal infection during the first half of pregnancy is linked to 10% more fetal loss and 3% more occurrences of hydrops fetalis. Congenital abnormalities or long-term sequelae have been attributed to parvovirus B19 infection. We are presenting a case of 34 years old teacher conceived through IVF with five months of amenorrhea with leaking per vaginum and spotting. She was diagnosed with severe oligohydramnios and IgG positive status which previous history of parvovirus infection and had twin fetal demise both of which presented with hydrops fetalis.

Keywords: Parvovirus B19, fetal, infection, hydrops, anemia

Medical Science, 2022, 26, ms314e2321

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DOI: https://doi.org/10.54905/disssi/v26i125/ms314e2321

Published: 27 July 2022