Volume 26, Issue 125, July 2022

A lethal encounter with malignant mixed germ cell tumour in an adolescent girl: A double trouble

Manisha Andela^1♦, Deepika Dewani², Kalyani Mahajan², Subhada Jajoo³, Srinidhi Cherukuri¹

¹Post graduate resident, Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India
²Associate Professor, Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India
³Professor, Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India

^♦Corresponding author
Post graduate resident, Department of Obstetrics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Deemed to be University, Sawangi (Meghe), Wardha, Maharashtra, India

ABSTRACT

Ovarian carcinomas are rarely encountered among paediatric population. Malignant germ cell tumours are comparatively uncommon ovarian neoplasms constituting less than 5%. Germ cell tumours consisting of numerous types, mainly including teratomas and dysgerminomas, accounts for around 10-15 % of ovarian tumours. Germ cell tumours are found to represent the malignant transformation of primordial germ cells. We discuss a case of 11 year-old girl who was been referred to our rural tertiary care centre with complaints of excruciating abdominal pain associated with abdominal distension. Patient was investigated elaborately and was found to have abnormally elevated tumour markers. Her CECT revealed an enormous tumour mass covering the entire pelvic region. Timely intervention was carried out by performing a cytoreductive surgery followed by frozen section evaluation which confirmed mixed germ cell tumour. Histopathological examination which was carried out elaborately has revealed the tumour was in advanced stage. Then the patient was started on chemotherapy. This case emphasizes that though mixed germ cell tumour among adolescents is rare condition, it is extremely important for the clinicians to be vigilant as it is often mismanaged especially in the rural centres where there is to dearth of resources and investigations.

Keywords: ovarian neoplasms, mixed germ cell tumour, adolescents, yolk sac tumour, dysgerminoma

Medical Science, 2022, 26, ms313e2320

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DOI: https://doi.org/10.54905/disssi/v26i125/ms313e2320

Published: 27 July 2022