Volume 26, Issue 125, July 2022

Vitamin D3 deficiency in babies and children with cholestasis

Mostafa Al-Bassam^1,2♦

¹Department of Chemistry and Biochemistry, College of Medicine, AlNahrain University, Baghdad, Iraq
²Assistant Lecturer at Department of Pharmacy, Al_Esraa University College, Baghdad, Iraq

^♦Corresponding author
Department of Chemistry and Biochemistry, College of Medicine, AlNahrain University, Baghdad, Iraq; Assistant Lecturer at Department of Pharmacy, Al_Esraa University College, Baghdad, Iraq

ABSTRACT

Background: Cholestasis, also known as prolonged jaundice, is characterized by a reduction in bile flow. Vitamin D3 is a fat-soluble vitamin whose absorption is affected by bile acids passing through the bile ducts. The primary objective was to determine the clinical utility of serum vitamin D3 in infants and children with cholestasis. Materials and Methods: Using an enzyme-linked immunosorbent assay, vitamin D3 levels in the blood serum of sixty patients with cholestasis, twenty patients with non-cholestatic causes, and twenty-five healthy subjects ranging in age from one day to fourteen years were determined. Results: Comparing intra- and extra-hepatic cholestasis groups to the control group, intra- and extra-hepatic cholestasis groups showed a highly significant decrease in serum vitamin D3 (P<0.001), while there was no significant difference between the control and non-cholestatic jaundiced groups (P= 0.069), and there was no significant difference between the old and newly diagnosed intra-hepatic cholestatic groups (p = 0.627). Conclusion: The amount of vitamin D3 in the serum of those with extra-hepatic cholestasis is lower than those with intra-hepatic cholestasis, indicating a poor prognosis for cholestasis illness.

Keywords: Extrahepatic Cholestasis, Fat-soluble Vitamins, Intrahepatic Cholestasis, Obstruction of Bile flow, Vitamin D3

Medical Science, 2022, 26, ms301e2308

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DOI: https://doi.org/10.54905/disssi/v26i125/ms301e2308

Published: 24 July 2022