Volume 26, Issue 125, July 2022

Type II Lissencephaly with chronic epilepsy and behavioral disturbances: A rare case report

Ajinkya Sureshrao Ghogare

Consultant Psychiatrist, Manoday Mansopchar Clinic, Akot, Akola, Maharashtra, India

ABSTRACT

Lissencephaly is a rare genetic disorder of brain malformation. It is characterized by the absence of normal folds or convolutions of the cerebral cortex. It is caused by abnormal neuronal migration during a period of embryonic development. It has various symptoms such as difficulty in swallowing, unusual facial appearance, abnormal muscular spasms, failure to thrive, extreme psychomotor retardation, deformities of fingers, toes, or hands, intellectual disability, and the seizure episodes. There are two variants of Lissencephaly namely type I and II. This case report has highlighted a rare case of type II Lissencephaly with chronic epilepsy and behavioral disturbances in a 12-year-old child managed effectively with a mood stabilizing antiepileptic drug named Divalproex sodium and a benzodiazepine named Clobazam.

Keywords: Epilepsy, Seizures, Behavioral disturbances, Lissencephaly, Divalproex sodium, Clobazam

Medical Science, 2022, 26, ms288e2145

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DOI: https://doi.org/10.54905/disssi/v26i125/ms288e2145

Published: 18 July 2022