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Volume 26, Issue 125, July 2022

The consequences of the arbitrary herbal and analgesics on renal function

Fatmah Fahad Alreshidi1, Ebtehaj Saud ALmughais1, Rana Aboras2, Rasha Alarfaj3, Samiah Ahmed Almehmadi4, Abdulazizi Ahmad Mohsen Alrashidi5, Taghreed Khulaifsaad Alrashidi6, Alzabni Faihan Obaid H7, Hussain Gadelkarim Ahmed8

1Department of Family and community medicine, College of Medicine, University of Hail, Hail, Saudi Arabia
2Department of Community Medicine, Faculty of Medicine, University of Hail, Ha’il 55476, Saudi Arabia
3Department of Family and Community Medicine, Unaizah College of Medicine and Medical sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia
4Consultant family medicine, Lifestyle medicine specialist, Ministry of Health, Hail Health cluster, Saudi Arabia
5Ministry of National Guard, Health affairs, Riyadh, Saudi Arabia
6Ministry of Health, Riyadh, Saudi Arabia
7Ministry of Health, Health affairs, Hail, Saudi Arabia
8Department of Histopathology and Cytology, FMLS, University of Khartoum, Sudan

♦Corresponding author
Department of Histopathology and Cytology, FMLS, University of Khartoum, Sudan

ABSTRACT

Background: Many modifiable risk factors have been linked to the etiology of the increased renal disease worldwide. The objective of this study was to assess the consequences of arbitrary herbal and analgesics on renal function in a series of Saudi patients. Methodology: This study investigated 2944 Saudi volunteers who have joined during a cross-sectional survey conducted in Hai'l region. Renal function status was established corresponding to Glomerular infiltrating Rate (GFR) estimation using creatinine level, age, and sex. GFR was categorized into: Stage III CKD (GFR = <60 - 30 mL/min). Stage IV (GFR = <30 – 15 mL/min). Stage V (GFR = <15 mL/min). Results: Around 14.4% of participants claimed using non-steroidal anti-inflammatory drugs (NSAIDs). Of the 391 analgesics users, about 12.8% were found with impaired renal function. The risk of analgesics uses in deteriorating renal function, the relative risk (RR) and the 95% confidence interval (95%CI), RR (95%CI) = 1.7926 (1.3313 to 2.4137), P = 0.0001. Out of the 426/2714(15.7%) herbal users, 45/426(10.6%) were found with impaired renal function. The risk of herbal uses in deteriorating renal function, the RR (95%CI) = 1.3659 (1.0366 to 1.7999), P = 0.0268. Conclusion: Significant Reverse associations between arbitrary herbal use as well as, frequent NSAIDs renal function. The frequent use of Arbitrary herbal and NSAIDs is common among the Saudi Community, particularly among women.

Keywords: NSAIDs, GFR, herbal medication, renal function, Saudi Arabia

Medical Science, 2022, 26, ms280e2369
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DOI: https://doi.org/10.54905/disssi/v26i125/ms280e2369

Published: 14 July 2022

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