Background: There is a prevalence of vitiligo in Saudi Arabia, with low reports regarding the burden of the disease. Thus, the current
study aimed to assess the knowledge and perception of vitiligo in Saudi Arabia. Methodology: This cross-sectional study involved
1004 volunteers’ participants living in the city of Hai'l, Northern Saudi Arabia. Contributors were selected randomly regardless of
age or sex. A purposeful questionnaire was designed and used to collect data regarding vitiligo. Results: About 77% claimed to
know what vitiligo is. The Odds Ratio (OR) and 95% confidence interval (95%CI) for Knowledge was OR (95%CI) = 1.193 (1.032-
1.378), P-value = 0.007. The most common source of knowledge was the internet, followed by physicians and friends, constituting
25%, 23%, and 13%, respectively. Conclusion: The knowledge and perception of vitiligo are averages among the Saudi community.
Distribution of educational and awareness materials through internet and social media can potentially reduce negative attitudes
toward vitiligo patients and improves their life quality.
Keywords: vitiligo, melanocytes, skin, Saudi Arabia