Volume 26, Issue 123, May 2022

Evaluation of effect of intravenous dexmedetomidine infusion on intra-operative hemodynamic and recovery profile in patients undergoing intracranial surgery under general anaesthesia

Harindranath S Kumar^1♦, Anjali Modak², Neeta Verma², Sheetal Madavi³, Nikhil Bhalerao⁴

¹Junior Resident, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India
²Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India
³Associate Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India
⁴Assistant Professor, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India

^♦Corresponding author
Junior Resident, Department of Anaesthesiology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India

ABSTRACT

Background: The brain is critically dependent on uninterrupted blood flow for the supply of nutrients and clearance of metabolites. Both an increase and decrease in the blood flow are harmful to the brain. Aim: This study aimed to evaluate the effectiveness of Dexmedetomidine (in comparison to normal saline) in maintaining haemodynamic parameters during laryngoscopy among patients undergoing elective intracranial surgery. Material and methods: This was a single centre, parallel-group, 1:1, and singleblind, placebo-controlled, randomised control study. 60 patients undergoing elective neurosurgery were randomised to intravenous dexmedetomidine (0.4mcg/kg/hr) or a similar volume of normal saline. Following outcomes were measured: heart rate, mean arterial pressure (MAP), the dose of thiopentone, time to extubation, and level of sedation. Results: The time for extubation in the Group D group was 5.23 minutes and in the Group C group, it was 8.6 minutes (p<0.0001). At endline, the sedation score among participants in group D was less in comparison to participants in group C. The mean dose of thiopentone required in group D participants was significantly less than those required by participants in group C (p<0.0001). Dexmedetomidine effectively blunted the increase in heart rate and mean arterial pressure both at intubation and extubation. There was a difference of 21% point between the MAP values between group D and group C participants at intubation. Conclusion: Dexmedetomidine has an anaesthetic sparing effect, and it reduced the time of recovery among patients undergoing neurosurgery.

Keywords: Laryngoscopy, Intubation, Dexmedetomidine, Neurosurgery

Medical Science, 2022, 26, ms194e2254

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DOI: https://doi.org/10.54905/disssi/v26i123/ms194e2254

Published: 28 May 2022