Introduction: A powerful technological breakthrough in recent decades has provided instrumental solutions to important medical
problems. The increased attention of many researchers was drawn to the evaluation and implementation in various medical
specialties of a wide range of modern laboratory methods based on the achievements of biology, biophysics, morphology,
mathematics and other sciences. This article provides information on the possibility of studying the physiological state of
myocardial tissue, taking into account it optical activity and ability to be birefringent. The method of statistical Mueller-matrix
analysis is analyzed, which is derived from the process of polarization visualization of the architectonic construction of normal
heart muscle and influenced by pathology. The biological tissue from an optical point of view as a combination of amorphous and
polycrystalline components are theoretically substantiated. The results of scientific research on the possibility of using the method
of polarization microscopy for the diagnosis of pathological conditions of the heart muscle are presented
Keywords: polarizing microscopy, biological tissues, laser, amorphocrystalline structure, myocardial tissue