Volume 26, Issue 123, May 2022

Evaluation of the association between progesterone levels on the day of HCG injection and the clinical outcomes of IVF treatment cycles in infertile women

Masoumeh Rezaei¹, Fariba Seyedoshohadaei¹, Nasrin Soufizadeh², Mohamad Jafar Rezaei³, Tayyebe Ghazavi^4♦

¹Associated professor, Obstetrics and gynecology Department infertility ward, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
²Associated professor, Department of Obstetrics and Gynecology, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
³Associated Professor of Anatomy, Kurdistan University of Medical Science, Department of Anatomy, Infertility Center of Besat Hospital. Sanandaj, Iran
⁴Resident of Obstetrics and Gynecology, Besat hospital, Medical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran

^♦Corresponding author
Resident of Obstetrics and Gynecology, Besat hospital, Medical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran

ABSTRACT

Introduction: Progesterone has a major role in menstrual cycles as well as implantation of fertilized oocytes and induction of pregnancy, but its effects on controlled ovarian stimulation cycles are still debated. The aim of this research was to investigate the association between progesterone levels on the day of HCG injection and the clinical outcomes of IVF treatment cycles in infertile women. Materials and Methods: The present research is a cross-sectional descriptive-analytical study. The study population included 300 infertile women, and then had IVF by Gnarl agonist and antagonist cycles in the infertility clinic of Besat Hospital in Kurdistan. Patient records and researcher-made checklists were used for collecting the data, and SPSS 24 software was implemented for analyzing the data. Results: Of the total patients studied, 224 people (74.7%) had progesterone levels less than 1.5, and 76 (25.3%) had progesterone levels greater than 1.5. The average age of patients was 33 years old and the mean duration of infertility was and 5.73 years. 79.3% of women had primary infertility and 20.7% had secondary infertility. There was no considerable association among progesterone levels and type of infertility, agonist and antagonist cycles, age and oocyte count (P > 0.05), implantation rate, clinical pregnancy, and spontaneous abortion. However, the progesterone levels had a considerable association with the grading and quality of oocytes. Conclusion: The findings indicated that cases with progesterone level less than 1.5 have higher fertility rates compared to cases with progesterone level greater than 1.5 (P-value = 0.6).

Keywords: Progesterone, HCG injection, Clinical outcome, IVF, Infertile women

Medical Science, 2022, 26, ms168e2120

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DOI: https://doi.org/10.54905/disssi/v26i123/ms168e2120

Published: 09 May 2022