Objective: Major depressive disorder (MDD) is associated with cognitive deficits and inflammation which predict treatment resistance. This study aimed to investigate the efficacy of Curcumin in cognitive functions and inflammation in depression. Methods: The present study was a double-blind, randomized clinical trial design. One hundred twenty MDD outpatients, aged 18 to 55, were selected regarding the inclusion and exclusion criteria and randomly assigned to Curcumin (n = 60) and control groups (n = 60). Participants were assessed at baseline, sixth and twelfth week for depressive symptoms and cognitive functions. Inflammatory markers (IL-6, IL-1β) were measured at baseline and the twelfth week. Both groups received sertraline. Experimental group received Curcumin while the control group received placebo. Data were analyzed by repeated measures MANOVA. Results: Curcumin out performed control on trial making test-B (P= 0.011), backward digit span, verbal fluency task and Tower of London (P< 0.001) at the twelfth week of assessment and forward digit span (P<0.001) and trial making test-A (P=0.041) at the sixth and twelfth week of assessment. Moreover, inflammatory markers reduced in the curcumin group more than in the control group (P< 0.011).
Objective: Major depressive disorder (MDD) is associated with cognitive deficits and inflammation which predict treatment resistance. This study aimed to investigate the efficacy of Curcumin in cognitive functions and inflammation in depression
Background: Due to the importance of pressure ulcers (PUs), this study was performed to determine the status of pressure ulcers in patients admitted to hospitals in Ilam.
Articular tuberculosis (AT) is caused mainly by Mycobacterium Tuberculosis (TB). Due to the infrequent presentation of the AT cases, there is a high probability of a misdiagnosis or delay of the accurate diagnosis that in most occasions results in inadequate therapy resulting in irreversible joint deterioration.
Swyer James Macleod syndrome (SJMS) is a seldom reported manifestation of post infectious obliterative bronchiolitis in childhood. This cause obliteration of peripheral airways and vascularity of the infected lung and impede lung development
Objective: To assess the prevalence of irritable bowel syndrome (IBS) and its subtypes in patients with polycystic ovary syndrome (PCOS), determine its associated factors, and compare the quality of life (QOL) of PCOS patients with and without IBS
Introduction: Respiratory tract infections consist of many diseases such as colds, pharyngitis, tonsillitis, influenza and respiratory diseases. Therefore, this meta-analysis study was performed to assay the effect of zinc, selenium, vitamin D, vitamin C on respiratory tract infections
Wilson’s disease presents with a wide clinical spectrum, most common being hepatic involvement and neuro-psychiatric features. Hepatopulmonary syndrome (HPS) is one of the rare complications of liver failure presenting as breathlessness, platypnea, orthodeoxia and central cyanosis
Background/Aim: The neurodiagnostic test known as ‘Intraoperative Neurophysiological Monitoring’ (IONM) is critically important in providing live-feedback during neurosurgery on the functional integrity of the nervous system.
Background: Acute Gastroenteritis (AGE) is an emerging infectious disease-causing pediatric morbidity and mortality worldwide. Method: A cross-sectional Arabic language anonymous questionnaire-based study was performed among the Saudi mothers' population October – December 2021
Background: COVID-19 still poses a threat to healthcare workers (HCW). Aim: Study knowledge and attitude of the HCWs of King Abdulaziz Specialist Hospital (KASH), Taif, Saudi Arabia, about COVID-19 and the vaccine rollout
Background: In Saudi Arabia the number of palliative care PC experts is relatively low, so most PC work is done by doctors who have recently graduated. Moreover, PC is not a mandatory course in medical school but can be taken as an elective.
Study Design: Double-blinded Randomised Controlled Trial. Participants: 20 asymptomatic individuals with mean age of 23.60 ± 1.85 years (12males, 8 females) were included by random sampling into two groups, one was given visual feedback (experimental) & the other without feedback (control).
Objective: Practitioners of forensic medicine assist with medicolegal investigations by providing expert medical advice to law enforcement during pathological investigations.
Background: An endo-perio lesion is defined as inflammation on a tooth that is associated with both pulpal and periodontal pathology. Endodontic-periodontic lesions are a clinical difficulty to diagnose and treat properly
Background: Rheumatic heart disease (RHD) is an infectious disease that encompasses a global health dilemma. Early diagnosis and appropriate management of pharyngeal infections by group (A) streptococci are significant in prevention of RHD.
Bladder cancer (BC), one of the urothelial carcinoma (UC) and colorectal cancer (CRC) are Lynch syndrome’s manifestations. In this case report, a 56 years old woman was admitted to ER with intermittent
Erythema multiforme is one of the acute and recurrent skin lesions that are usually seen soon after HSV infection. The distribution of lesions is usually symmetrical favoring distal extremities
Pneumonia is a complex pulmonary disease caused by inflammation of lower respiratory tract frequently affecting infants, young children and elderly people. Bronchopneumonia is the commonly seen presentation of pneumonia occurring mainly in paediatric population.
Coronavirus disease 2019 has been a pandemic outbreak since December 2019. It was notified in Wuhan, China in in December 2019, has rapidly swept around the world, causing a great threat to global health
Background: Depending on the findings of the hearing test, a kid may be diagnosed with hearing loss if they can't hear sounds below a specific volume level in either one ear (known as unilateral) or both ears (bilateral).
Background: The etiology of childhood cancer remains unclear, although current research suggests that the uterine environment has a significant impact. The objective of this review is to investigate the 5-minutes and 1-minute APGAR scores as a predictor risk factor for cancer development among the pediatric population
Depression is repeated sequel among patients with traumatic brain injury (TBI). The purpose of our research is to identify the prevalence of depression after TBI. It is a prospective, study carried out in the first two year after brain trauma occurred
Background: Breast cancer (BC) is the commonest cancer among Saudi women. Awareness about its screening among females is a crucial issue for early detection of breast abnormalities and interference to reduce its complications
Introduction: hippocampus and amygdala believed to be central to the cognitive deficits associated with depression. The former has a crucial role in declarative memory, whereas the latter is the center that is responsible for fear and anxiety
Introduction: Osteoporosis is a systemic disease that is characterized by a decline in the mass of bone leading to bone thinning and fragility that, in turn, leaves patients highly vulnerable to bone fractures
Aim: Patients who have severe case of kyphoscoliosis face functional and physical difficulties, making anaesthetic treatment challenging. In this example, a severe case of scoliosis was successfully treated under general anaesthesia.
This study looked at the gastroprotective effects of chamomile, sesame, and flax oil extracts on experimental rats with piroxicam-induced stomach ulcers. In this investigation, 36 albino rats weighing 100-10 g were separated into 6 groups
Introduction: Stroke is the most dreadful complications post cardiac surgery. In spite of advances in surgical techniques, its incidence still 3 to 5%, with associated mortality up to 26%. It’s more post valve surgery
Objective: To analyse the effects of the COVID-19 outbreak on behavior management strategies in paediatric dentistry. Study Design: For this cross sectional research, before the COVID-19 pandemic and after the lift of lockdown during COVID-19 pandemic
Background: The existing recommendations for the diagnosis and treatment of anal cryptoglandular transsphincteric fistulas (AF) are contradictory, which makes practical decisions in its treatment extremely difficult
Introduction: The primary prevention of chronic non-communicable diseases (NCDs) is based on health promotion activities aiming to protect people against unhealthy lifestyle behaviours
Background: Breast cancer incidence rate has risen and consider one of the most frequent malignancy worldwide. Surgery is continuously the most appropriate way for curing breast cancer; breast reconstruction is an important stage for breast cancer management and improves breast appearance
Background: During the period of COVID-19 and as number of cases increase، shortages in healthcare workers (HCWs) is a concern. Subsequently, the workload of HCWs may be substantial
Aims: The study objective was to assess the association between social media advertisements related to veneers and lumineers and the treatment decision made by the patients.
Background: Adenomyosis of uterus is difficult to diagnose clinically because of nonspecific symptoms and signs. Accurate diagnosis can be achieved with imaging
Background: The Avulsion of triceps muscle tendon is a very uncommon tendinous damage. Avulsions could be partial and/or entire, and they can be fractured or not
Objective: Color Doppler sonography and flow velocimetry of fetal UA, MCA, and RA for accurate prediction of perinatal outcome in fetal growth retardation. Material and methods: Prospective study of 200 singleton pregnancies having FGR (24-39 weeks).
Background: The lack of an effective antiviral treatment in the COVID 19 pandemic is increasing the importance of vaccines day by day. Materials and Methods: The study was scheduled between October 1, 2021 and January 7, 2022.
Introduction: Aging is a normal process for human beings associated with numerous issues, one of which is depression that is common among elderly. This study aims to estimate the prevalence of depression and identify associated factors among senior residents in a nursing home in Makkah, thus aiding in promoting seniors’ psychological health
