Volume 26, Issue 120, February 2022

Obesity as a risk and predictive factor for ovarian cancer among Saudi women: Hypothetical cloned artistic projection

Abdulaziz Alorwan^1♦, Mahdya Bukhari², Omer Quayidkhalanazi³

¹Senior Resident, Department of obstetrics and Gynecology, College of medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia
²Senior resident, Department of obstetrics and Gynecology, College of medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia
³Senior Resident, Family Medicine Department, Royal medical service, Jordan university of Yarmouk, Irbid -Jordan

^♦Corresponding author
Senior Resident, Department of obstetrics and Gynecology, College of medicine, King Saud University, King Saud University Medical City, Riyadh, Saudi Arabia

ABSTRACT

Objective: The goal of this research was to investigate the role of body mass index (BMI) as a risk and prognostic factor for ovarian cancer in Saudi women. Methods: The data of 937 ovarian cancer patients treated in Saudi Arabia between January 2020 and October 2021 were studied in this cloned duplicated hypothetical view point. Four age-matched controls from healthy women were selected to assess sickness risk based on BMI (1-year age group). Results: Obese (BMI >25 kg/m2) and overweight (BMI >23 kg/m2) women had a greater cancer incidence than non-obese (BMI b23 kg/m2) women (OR=3.161, 95 percent CI=2.655–3.763 and OR=1.536, 95 percent CI=1.260–1.873, respectively). In other words, a rise of 1 kg/m2 raised the risk of ovarian cancer by 18% (OR=1.181, 95 percent CI=1.155–1.207). Overall survival, however, did not change based on BMI categories (log-rank=0.366, p=0.8328). The crude Cox model found that obesity was not associated with overall survival when obese and non-obese women were compared (crude HR=0.82, 95 percent CI=0.40–1.66). Furthermore, there was a significant trend toward a better prognosis as BMI increased (p for trend b 0.001), despite the fact that this was not detected in the multivariate analysis. Conclusions: A high BMI was shown to be a substantial risk factor for ovarian cancer in the Saudi population. Despite the early tumor stage in the obese women, it was not associated with overall survival.

Keywords: Obesity, Risk, Predictive Factor, Ovarian Cancer, Saudi, Women

Medical Science, 2022, 26, ms60e2016

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DOI: https://doi.org/10.54905/disssi/v26i120/ms60e2016

Published: 08 February 2022