Volume 25, Issue 118, December 2021

Protein S deficiency presenting with portal vein thrombosis in a non-cirrhotic pregnant woman: Case report and review of literature

Ahmed Alshammari

Department of Internal Medicine, College of Medicine, University of Hail, Hail, Saudi Arabia

ABSTRACT

A 27-year-old primigravid patient presented with severe abdominal pain during the 10th week of gestation. Blood test results, including those of lipase and liver enzymes, were unremarkable. However, doppler ultrasonography of the abdomen revealed left portal vein thrombosis. Therapeutic enoxaparin was initiated, resolving the pain. At week 25 of gestation, the patient went into labor and delivered, vaginally, a single, live male infant. The newborn died within one week. Postpartum, she underwent further investigation to identify the cause of portal vein thrombosis. A thrombophilia workup revealed low protein S activity. This case highlights the importance of performing a thrombophilia workup in women with portal vein thrombosis during pregnancy.

Keywords: portal vein thrombosis; protein S deficiency; pregnancy; thrombophilia; enoxaparin; abdominal pain

Medical Science, 2021, 25(118), 3417-3420

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