Volume 25, Issue 118, December 2021

A malignant transformation of benign phyllode tumor of breast and its management: A case report from India

Meenal Rajput^1♦, Md. Jawed Akhter², Lamture YR³, Gaurav Jagtap⁴

¹Junior Resident Medical Officer, Department of Surgery, Shri Shankaracharya Institute of Medical Science, Junwani, Durg-490020, Chhattisgarh, India
²HOD & Professor, Department of Surgery, Shri Shankaracharya Institute of Medical Science, Junwani, Durg-490020, Chhattisgarh, India
³Professor, Department of Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India
⁴Junior Resident, Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha-442001, Maharashtra, India

^♦Corresponding author
Junior Resident Medical Officer, Department of Surgery, Shri Shankaracharya Institute of Medical Science, Junwani, Durg-490020, Chhattisgarh, India;

ABSTRACT

Phyllode tumor (PT) of a breast is mostly benign, it shows a very rare transformation into malignant PT. Globally, less than a percentage of cases get reported for breast tumors. We reported the case of a recurring tumor in a woman of age 48 years with a lump on her left breast. She has gone through a resection twice. Firstly, post excision H/P reported fibroadenoma. Secondly, the excision of benign PT transformed to malignant phyllode within 3 months of resection. The results from images of CT scan, intraoperative, and pathological slides from the specimen of mastectomy have made us conclude that the malignant transition is caused by a mutation in residual tumor cells. Then, the total mastectomy with low axillary lymphadenectomy was done. Further, the patient was advised for adjuvant chemotherapy within 2 weeks and radiation therapy to the chest within 4 months of surgery. The patient is also advised to attend the follow-up appointments with the oncologist monthly for a minimum of 2 years after completion of adjuvant chemoradiotherapy

Keywords: Breast, Benign phyllode tumor, Recurrence, Malignant transformation, malignant phyllode tumor

Medical Science, 2021, 25(118), 3231-3236

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